PARCPolysubstance Addiction Research Center

Cores

Center Cores

Five cores provide the shared infrastructure of the center, from standardized behavioral phenotyping to data integration, biobanking, and pilot funding.

How cores and projects work together

Staircase diagram of the center's five cores and three projects with their impacts: the Administrative Core provides leadership, governance, training, and organization; the Pilot Projects Core funds early-stage innovative studies; the Behavioral Phenotyping Core provides robust preclinical models of addiction-like behaviors; the Addiction BioBank Core provides rigorously collected samples and serves as a national resource; the Computational Analytical Core integrates data from all cores and projects and ensures data are FAIR; the Gut-Vagus Multi-omic project investigates drug influences on gut-brain communication; the Brain Transcriptomic project uncovers cell-specific transcriptomic changes; and the Brain Connectomic project maps brain-wide network changes and convergent hubs.
The five cores and three research projects, and the impact of each. (Figure from the PARC research proposal.)
Circular network diagram showing dense interconnections among the Addiction BioBank Core (standardized biospecimens across drugs, sexes, and timepoints), Behavioral Phenotyping Core (testing the causal role of biological targets on addiction-like behaviors), Computational Analytical Core (integration of behavioral, omics, and imaging data), and the Brain Connectomic, Brain Transcriptomic, and Gut-Vagus Multiomic projects.
Every project draws on every core: standardized biospecimens, causal behavioral testing, and integrated computational analysis. (Figure from the PARC research proposal.)