PARCPolysubstance Addiction Research Center

Publications

Publications

Peer-reviewed publications by PARC investigators since 2020. Filter by investigator or topic, or search.

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2026

  • New · added Sep 25 Addiction-like behavioral severity predicts prolonged oxycodone withdrawal-induced allodynia in genetically diverse rats. PARC OpioidsGeneticsBehavior Plasil SL, Tieu L, Qian C, Taylor N, Coe S, Sneddon E, Carrette LL, Brennan M, Morgan A, Othman D, Bai K, Foroutani S, de Guglielmo G, Kallupi M, George O. Neuropharmacology. 2026 Sep. PMID: 42790729 DOI
  • New · added Sep 21 Author Correction: Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. Rickner HD, Jiang L, Hong R, O'Neill NK, Mojica CA, Snyder BJ, Zhang L, Shaw D, Medalla M, Wolozin B, Cheng CS. Nat Commun. 2026 Sep. PMID: 42768023 DOI
  • New · added Sep 26 Cord Blood Adductomic Profiling Provides Preliminary Insights on Perinatal Smoking Exposure: A Pilot Analysis. Gut–Brain Newar J, Brees E, Lin ET, Chakraborty A, Abanes A, Fisch KM, Funk W, Mestan KK. Antioxidants (Basel). 2026 Aug. PMID: 42792117 DOI
  • SMRT regulation of nuclear receptors orchestrates bile acid homeostasis. Gut–Brain Kim K, Fang S, Hong SH, Cho H, Leblanc M, Jacinto S, Schnabl B, Atkins AR, Yu RT, Liddle C, Truitt ML, Fan W, Lee CM, Downes M, Evans RM. Exp Mol Med. 2026 Sep. PMID: 42717237 DOI
  • A 3D-Printed Microvascular Surgery Training Platform With High-Fidelity, Biomimetic Properties. Brain Imaging Huang L, Narotam K, Berman E, Park A, Guan J, Llaneras J, Leach G, Carrette L, Abrams R, Berry DB, Chen S. Small. 2026 Aug. PMID: 42656126 DOI
  • Passive nicotine vapor exposure model in mice reveals translationally relevant dose-dependent cotinine levels and withdrawal behaviors. NicotineGut–BrainBehavior Zahedi S, Carrette LLG, China L, La T, Mosquera J, Martinez AR, de Guglielmo G, Ambroggi F, George O. J Neurosci Methods. 2026 Aug. PMID: 42636982 DOI
  • Targeting microbial bile salt hydrolase reprograms bile acid metabolism and ameliorates metabolic dysfunction-associated steatohepatitis in mice. Gut–Brain Wei W, Graf R, Wang Y, Oalmann CJ, Lau JT, Wang X, Chien M, Conrad MC, Simon J, Ganguly S, Yamazaki T, Harberts A, Chen S, Fondevila MF, Dhar D, Campbell AS, Senter RK, Schnabl B. Mol Metab. 2026 Aug. PMID: 42612975 DOI
  • Candidalysin drives pyroptosis of intestinal epithelium to exacerbate IBS by suppressing HDAC2-mediated deacetylation of GSDMD-K194. Gut–Brain Liu A, Ai Y, Yang P, Zhang L, Hong G, Schnabl B, Xu K, Cai K, Hou X, Chu H. J Adv Res. 2026 Aug. PMID: 42571846 DOI
  • Letter: Major Adverse Outcomes in Steatotic Liver Disease Subtypes-From Etiological Classification to Biological Phenotyping: Authors' Reply. Gut–Brain Miwa T, Schnabl B. Aliment Pharmacol Ther. 2026 Aug. PMID: 42543783 DOI
  • Attentional Bias During a Novel Alcohol Cue Virtual Reality Paradigm. Alcohol Sullivan RM, McKenna BS, Liu W, McKinty A, Laurance C, Rush CR, Weibel N, Courtney KE. Alcohol Clin Exp Res (Hoboken). 2026 Aug. PMID: 42538610 DOI
  • Acute opioid responses are modulated by dynamic interactions of Oprm1 and Fgf12. PARC OpioidsGeneticsBehavior Lemen PM, Zuo Y, Hatoum AS, Dickson PE, Mittleman G, Agrawal A, Reiner BC, Berrettini W, Ashbrook DG, Gunturkun MH, Wang X, Mulligan MK, Brown CJ, Nestler EJ, Telese F, Williams RW, Chen H. Elife. 2026 Jul. PMID: 42525548 DOI
  • Integrative multi-omics analysis identifies stellate cell-derived complement component 7 as a predictor of fibrosis and liver-related events in MASLD. PARC Gut–Brain Kondo S, Kimura T, Iwadare T, Taufeeq M, Miwa T, Fujimori N, Nakajima T, Wakabayashi SI, Okumura T, Kobayashi H, Yamashita Y, Isogai S, Yamazaki T, Iwaya M, Uehara T, Umemura T, Choudhary S, Schnabl B, Jain S, Tanaka N. JHEP Rep. 2026 Jul. PMID: 42486350 DOI
  • Non-absorbable antibiotics worsen alcohol-associated liver disease in gastric acid-suppressed mice. AlcoholGut–Brain Raya Tonetti F, Han H, Fondevila MF, Wei W, Özdirik B, Bajaj JS, Schubert ML, Sikaroodi M, Gillevet PM, Lang S, Demir M, Rahman IR, van der Donk WA, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Stärkel P, Bataller R, Hsu CL, Llorente C. Gut Microbes. 2026 Jul. PMID: 42421214 DOI
  • Data-driven RNA phenotyping captures genetically regulated dimensions of the transcriptome. Genetics Munro D, Gusev A, Palmer AA, Mohammadi P. Am J Hum Genet. 2026 Jul. PMID: 42392033 DOI
  • Intestinal neutral ceramidase, microbial metabolites and epithelial fucosylation in MASH. Gut–Brain Llorente C. eGastroenterology. 2026 Jun. PMID: 42403914 DOI
  • Genome-wide association study of cocaine self-administration behavior in Heterogeneous Stock rats. PARC AlcoholStimulantsNicotineGeneticsBehavior Lara MK, Carrette LLG, Sanches TM, Polesskaya O, Avelar A, Beeson A, Beldjoud H, Boomhower B, Brennan M, Chen D, Cheng R, China L, Chitre AS, Conlisk DE, Fannon M, Johnson BB, Keung E, Kimbrough A, Kononoff J, Martinez AR, Maturin L, Nguyen KM, Morgan A, Mosquera J, Othman D, Plasil SL, Ramborger J, Schweitzer P, Sedighim S, Seshie O, Shankar K, Sichel B, Simpson S, Smith LC, Sneddon EA, Tieu L, Velarde N, Zahedi S, Woods LCS, Kallupi M, de Guglielmo G, Palmer AA, George O. Nat Commun. 2026 Jun. PMID: 42277005 DOI
  • Single-cell transcriptomics reveals differences between chorionic and basal plate cytotrophoblasts and 2D-cultured trophoblast stem cells. Morey R, Soncin F, Kallol S, Sah N, Manalo Z, Bui TA, Slamecka J, Cheung VC, Pizzo D, Requena DF, Chang CW, Farah O, Kittle R, Lam K, Meads M, Horii M, Fisch KM, Parast MM. Commun Biol. 2026 Jun. PMID: 42270938 DOI
  • Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits. GeneticsBehavior Chitre AS, Hebda-Bauer EK, Emery MA, Li F, Nguyen KM, Wang Y, Cheng R, Polesskaya O, Watson SJ, Li J, Akil H, Palmer AA. Genes Brain Behav. 2026 Jun. PMID: 42145201 DOI
  • Faecal Cathepsin B and S Are Associated With Liver Disease Severity and Adiposity in MASLD. Gut–Brain Harberts A, Fondevila MF, Kreimeyer H, Miwa T, Lang S, Demir M, Schnabl B. Liver Int. 2026 Jun. PMID: 42093609 DOI
  • Derivation of functional early gestation decidual natural killer cell subtypes from induced pluripotent stem cells. Cheung VC, Jaimez J, DaCosta C, Arora H, Caron C, Slamecka J, Fierro M, Meads M, Fisch K, Morey RE, Cruz LS, Pant D, Kaufman DS, Horii M, Bui JD, Parast MM. Stem Cells. 2026 Jun. PMID: 41999228 DOI
  • Comparison of Deep Learning Tools for Optic Nerve Axon Quantification Finds Limited Generalizability Upon Independent Validation. Chuter B, Emmert N, Kim MY, Stiemke AB, Dave N, Herrin J, Zhou Z, Wall G, Lu L, Williams RW, Palmer AA, Chen H, Hollingsworth TJ, Jablonski MM. Bioengineering (Basel). 2026 May. PMID: 42351892 DOI
  • The development of FEDUPP: feeding experimentation device users processing package to assess learning and cognitive flexibility. Behavior Yao M, Libster AM, Desfor S, Malhotra F, Castorena N, Montilla-Perez P, Telese F. Transl Psychiatry. 2026 May. PMID: 42140909 DOI
  • Subtype Differences in Major Adverse Liver Outcomes and Cardiovascular Events and Mortality in Steatotic Liver Disease: A UK Biobank Analysis. PARC AlcoholGut–Brain Miwa T, Díaz LA, Harberts A, Yukawa-Muto Y, Nakamura T, Zhang X, Loomba R, Schnabl B. Aliment Pharmacol Ther. 2026 May. PMID: 42120953 DOI
  • Covert hepatic encephalopathy as a multi-organ syndrome: the gut-liver-muscle-brain axis, diagnosis, treatment, and multidisciplinary care. Gut–Brain Miwa T, Hsu CL, Shimizu M, Bloom PP, Schnabl B. J Gastroenterol. 2026 May. PMID: 42101655 DOI
  • Lactic acid bacteria and endogenous ethanol mediate proton pump inhibitor-associated MASLD: a multicohort cross-sectional mediation analysis. AlcoholGut–Brain Davids M, Herrema H, K Groen A, Galenkamp H, Zwinderman A, Palmu J, Havulinna A, Niiranen T, Knight R, Acherman Y, Franken R, Verheij J, Dukas M, Dutch Liver Pathology Panel, Bajaj J, Llorente C, Schnabl B, Nieuwdorp M, Meijnikman A. Gut Microbes. 2026 May. PMID: 42070114 DOI
  • Reply to: "Hepatic CTSB is Kupffer cell-enriched, whereas disease-state stratification is more strongly captured by endotoxin/TLR4 programmes". Fondevila MF, Schnabl B. J Hepatol. 2026 Apr. PMID: 42067145 DOI
  • Clinicogenomic Real-World Data Enable Prediction of Hospital Readmissions at a Comprehensive Cancer Center. Genetics Kalahasti NV, Donepudi G, Bauersfeld S, Jandu S, Tayal A, John DJ, Kacham S, Muruhathasan V, Ramsey C, Jang SS, Flagg M, Hogarth M, Califano J, Fisch KM. JCO Clin Cancer Inform. 2026 Apr. PMID: 42044461 DOI
  • Novel candidate genes for vestibular function identified through GWAS in the hybrid mouse diversity panel. Genetics Ninoyu Y, Pan C, Luu J, Rashid S, Johnston J, Ortega B, Boussaty E, Lu L, Clifford R, Mohammadi P, Telese F, Palmer AA, Lusis AJ, Friedman RA. BMC Genomics. 2026 Apr. PMID: 41965519 DOI
  • Gut-liver axis molecular mechanisms in alcohol-associated liver disease. AlcoholGut–Brain Jiang Y, Llorente C. Alcohol. 2026 Apr. PMID: 41942011 DOI
  • Beyond Mendel: a call to revisit the genotype-phenotype map through new experimental paradigms. Genetics Tautz D, Pallares LF, Andersson L, Barghi N, Barton N, Bay R, Chan YF, Hancock A, Kaiser TS, Koenig D, Kontarakis Z, Liedvogel M, de Meaux J, Nordborg M, Palmer AA, Purugganan M, Schlötterer C, Schmid K, Stainier DYR, Weigel D, Wolf JBW, Ebert D, Gibson G. Genetics. 2026 Apr. PMID: 41701356 DOI
  • Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk. GeneticsBehavior Poore HE, Chatzinakos C, Leger B, Gonzalez J, Mallard TT, Aliev F, Hatoum A, Waldman ID, Sanchez-Roige S, Palmer AA, Harden KP, Dick DM, Barr PB. Nat Ment Health. 2026 Mar. PMID: 41987933 DOI
  • Parallel regulation of goblet cell-associated antigen passages by reduced microbial sensing and mAChR4 signaling in Muc2 deficiency prevents ethanol-induced liver injury. AlcoholGeneticsGut–Brain Raya Tonetti F, Han H, Freund L, Cabre N, Fondevila MF, Eguileor A, Mayo S, Stärkel P, Hsu CL, Llorente C. Hepatology. 2026 Mar. PMID: 41894257 DOI
  • Intestinal epithelial peroxisome proliferator-activated receptor γ deficiency exacerbates insulin resistance in mice with metabolic dysfunction-associated steatohepatitis. Gut–Brain Hsieh YC, Schnabl B, Huang YH, Hou MC, Lin HC, Lee KC. J Nutr Biochem. 2026 Mar. PMID: 41887537 DOI
  • Engaging Gut-to-Brain Signalling to Treat Alcohol Use Disorder. PARC AlcoholGut–BrainBehavior Hoffman PL, de Guglielmo G, Vengeliene V, Kunze W, Lebonville CL, Swinny JD, Roberts AJ, George O, McVey Neufeld KA, Dunbar A, Saba LM, Ma R, Vendruscolo LF, Becker HC, Spanagel R, Tabakoff B. Addict Biol. 2026 Mar. PMID: 41879717 DOI
  • High incidence of estrous cycle irregularities in heterogeneous stock (HS) rats is associated with footshock-resistant cocaine intake. PARC StimulantsGeneticsBehavior Sneddon EA, Chonwattanagul S, Bai K, Kurup PH, Plasil SL, Doyle MR, Zahedi S, Simpson S, Sichel BC, Othman DN, Brennan M, Palmer AA, Kallupi M, Carrette LLG, de Guglielmo G, George O. Psychopharmacology (Berl). 2026 Mar. PMID: 41874612 DOI
  • Long-read genome sequencing improves detection and functional interpretation of structural and repeat variants in autism. Genetics Mortazavi M, Guevara J, Diaz J, Tran S, Ziaei Jam H, Reeves C, Batalov S, Jepsen K, Bainbridge M, Besterman AD, Gymrek M, Palmer AA, Sebat J. Cell Genom. 2026 Mar. PMID: 41806827 DOI
  • When Inhibition Fails: Adolescent Nicotine Disrupts Opioid Control of Ventral Tegmental Area GABA Neurons. OpioidsNicotine Hollon NG, Hnasko TS. Biol Psychiatry. 2026 Mar. PMID: 41720559 DOI
  • Establishing Region-specific Testing Strategies for Minimal Hepatic Encephalopathy: Lessons and Future Perspectives from a Young, Literate Indian Cohort. Miwa T, Shimizu M, Schnabl B. J Clin Exp Hepatol. 2026 Feb. PMID: 41940142 DOI
  • Correction: Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament. Behavior Hebda-Bauer EK, Hagenauer MH, Munro DB, Blandino P, Meng F, Arakawa K, Stead JDH, Chitre AS, Ozel AB, Mohammadi P, Watson SJ, Flagel SB, Li J, Palmer AA, Akil H. Front Mol Neurosci. 2026 Feb. PMID: 41756766 DOI
  • FAK inhibition in ovarian cancer releases omega-3 fatty acids to program CXCL13-producing anti-tumor resident peritoneal macrophages. Chen XL, Tharp KM, Ojalill M, Ozmadenci D, Boyer A, Haanen TJ, Lawson C, Lee HJ, Xia M, Tahon E, Zhang Y, Minor C, Khan SU, Anderson CC, Nemkov T, Rose M, Estrada MV, Molinolo AA, Warren E, Penalosa P, Eskander RN, McHale MT, Wang SE, Connolly DC, Fisch KM, Stupack DG, Schlaepfer DD. Cell Rep. 2026 Feb. PMID: 41739646 DOI
  • Ivermectin reduces withdrawal-induced alcohol intake in rats: Association with CeA GABAergic enhancement and P2rx4 genetic liability. PARC AlcoholGeneticsBehavior Campo P, Qiao R, Doyle MR, Munro D, Johnson BB, Palmer AA, Kallupi M, de Guglielmo G. Neuropharmacology. 2026 Feb. PMID: 41690511 DOI
  • Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease. AlcoholGut–Brain Fondevila MF, Kreimeyer H, Hsu CL, Tamargo-Azpilicueta J, Day LZ, Gritsenko M, Attah K, Cabré N, Harberts A, Tonetti FR, Yang Y, Yamazaki T, Schöler D, Eguileor A, Blasio C, Meijnikman AS, Zhang X, Garcia-Carbonell R, Hook V, Zhou E, Sun Z, Jacobs JM, Turner JR, Llorente C, AlcHepNet Investigators, Glass CK, Stärkel P, Reinheckel T, Diaz-Moreno I, Gonzalez DJ, Schnabl B. J Hepatol. 2026 Feb. PMID: 41654223 DOI
  • Determinants of Placental Versus Maternal Preeclampsia. Gut–Brain Aisagbonhi O, Jacobs MB, Meads M, Stanley V, Lamale-Smith LM, Emeruwa UN, Laurent LC, Fisch KM, Horii M. Hypertension. 2026 Feb. PMID: 41636024 DOI
  • Large-scale behavioral characterization of oxycodone self-administration in heterogeneous stock rats reveals initial analgesic effects are associated with addiction-like behaviors. PARC OpioidsGeneticsBehavior Kallupi M, de Guglielmo G, Carrette LLG, Simpson S, Kononoff J, Kimbrough A, Smith LC, Shankar K, Avelar A, Conlisk D, Brennan M, Tieu L, Sedighim S, Boomhower B, Maturin L, Fannon MJ, Martinez A, Crook C, Dirik S, Velarde N, Schweitzer P, Bonnet-Zahedi S, Sneddon E, Plasil S, Morgan AA, Othman DN, Sichel B, Peng B, Chitre AS, Polesskaya O, Lau J, Vang A, Solberg Woods LC, Palmer AA, George O. Neuropsychopharmacology. 2026 Jan. PMID: 41617925 DOI
  • Fifteen years of the Diversity Outbred mouse model: a review. PARC StimulantsGeneticsBehavior Tatom Z, Miles MF, Palmer AA. Mamm Genome. 2026 Jan. PMID: 41606199 DOI
  • Incentive salience, not psychomotor sensitization or tolerance, drives escalation of cocaine self-administration in heterogeneous stock rats. PARC StimulantsBehavior Ramborger J, Mosquera J, Brennan M, Sichel B, Othman D, Plasil S, Sneddon E, Zahedi S, Morgan A, Chonwattanagul S, Bai K, China L, La T, Maturin L, Carrette LLG, George O. Neuropsychopharmacology. 2026 Jan. PMID: 41548027 DOI
  • Profiling active RNA polymerase II transcription start sites from total RNA by capped small RNA sequencing (csRNA-seq). Meyer MK, Olanrewaju OJ, Montilla-Perez P, McDonald AL, Rickard EM, Telese F, Benner C, Savenkova MI, Duttke SH. Nat Protoc. 2026 Jan. PMID: 41540114 DOI
  • APOBEC3B enhances the efficacy of PARP inhibitors in elimination of ovarian cancer stem cell. Rivera M, Liu L, Enlund S, Lim CE, Zhang H, Yang K, Sasik R, Crews LA, Fisch KM, Eskander RN, Holm F, Jiang Q. Sci Rep. 2026 Jan. PMID: 41535339 DOI
  • Gut microbial ethanol metabolism contributes to auto-brewery syndrome in an observational cohort. AlcoholGeneticsGut–Brain Hsu CL, Shukla S, Freund L, Chou AC, Yang Y, Bruellman R, Raya Tonetti F, Cabré N, Mayo S, Lim HG, Magallan V, Cordell BJ, Lang S, Demir M, Stärkel P, Llorente C, Palsson BO, Mandyam C, Boland BS, Hohmann E, Schnabl B. Nat Microbiol. 2026 Jan. PMID: 41507585 DOI
  • Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies. Gut–Brain Gao W, Yan S, Zhang L, Chen L, Che J, Huang W, Chen Y, Liu A, Zhu Y, Yang Y, Peng Z, Tan C, Schnabl B, Hou X, Yang L, Chu H. J Adv Res. 2026 Jan. PMID: 41490838 DOI
  • Bile salt hydrolase activity as a rational target for MASLD therapy. Gut–Brain Jones EV, Wang Y, Wei W, Reed JC, Chaudhari SN, Li DK, Boursier J, Lang S, Demir M, Diehl AM, Allegretti AS, Schnabl B, Chung RT, Devlin AS. Gut Microbes. 2026 Jan. PMID: 41481156 DOI

2025

  • Peptide YY reduces cytotoxicity of Candida albicans in alcohol-associated liver disease. AlcoholGut–Brain Kreimeyer H, Fondevila MF, Harberts A, Raya Tonetti F, Schöler D, Münte E, Hartmann P, Llorente C, Hube B, LeibundGut-Landmann S, Stärkel P, AlcHepNet Investigators, Schnabl B. JHEP Rep. 2025 Dec. PMID: 41996830 DOI
  • Metabolic dysfunction and alcohol-associated liver disease (MetALD). AlcoholGut–Brain Gao B, Arab JP, Liangpunsakul S, Ding WX, Szabo G, Mehal W, Wang H, He Y, Stärkel P, Llorente C, Schnabl B, Hwang S, Vandermerwe S, Gao Y, Zheng MH, Kim W, George J, Bataller R, Loomba R, Leggio L, Tacke F. eGastroenterology. 2025 Dec. PMID: 41459093 DOI
  • Genetic architecture and mechanisms of host-microbiome interactions from a multi-cohort analysis of outbred laboratory rats. GeneticsGut–Brain Tonnelé H, Chen D, Morillo F, Garcia-Calleja J, Chitre AS, Johnson BB, Sanches TM, Cheng R, Bonder MJ, Gonzalez A, Kosciolek T, George AM, Han W, Holl K, Horvath A, Ishiwari K, King CP, Lamparelli AC, Martin CD, Martinez AG, Netzley AH, Tripi JA, Wang T, Bosch E, Doris PA, Stegle O, Chen H, Flagel SB, Meyer PJ, Richards JB, Robinson TE, Solberg Woods LC, Polesskaya O, Knight R, Palmer AA, Baud A. Nat Commun. 2025 Dec. PMID: 41413022 DOI
  • Burden of malnutrition and sarcopenia in patients with cirrhosis: pathophysiology, assessment, and management. Gut–Brain Miwa T, Shimizu M, Schnabl B. Clin Mol Hepatol. 2025 Dec. PMID: 41398617 DOI
  • When the gut guards the liver: Microbial metabolites limit collateral damage after TACE. Gut–Brain Harberts A, Schnabl B. J Hepatol. 2025 Dec. PMID: 41344555 DOI
  • Delay discounting violations vary by adolescent sociodemographics: Excluding nonsystematic data may bias conclusions. Behavior Gelino BW, Felton JW, Hung IT, Strickland JC, Kahn GD, Thomas NS, Gowin JL, Sloan ME, Palmer AA, Sanchez-Roige S, Sanches MR, Yip SW, Maher BS, Rabinowitz JA. Exp Clin Psychopharmacol. 2025 Dec. PMID: 41343368 DOI
  • Single-cell transcriptomics reveals immune remodeling of the murine lung microenvironment following chronic house dust mite exposure. Chang H, Zeng L, Malakoutikhah Z, Nasamran CA, Herdman S, Corr M, Fisch KM, Webster NJG, Raz E, Bertin S. Front Immunol. 2025 Nov. PMID: 41445736 DOI
  • Genome-wide association study of delay discounting identifies 11 loci and reveals transdiagnostic associations across mental and physical health. GeneticsBrain ImagingBehavior Thorpe HHA, Cupertino RB, Pakala SR, Fontanillas P, Jennings MV, Yang J, Meredith JJ, Greenwood T, Bianchi SB, Vilar-Ribó L, Niarchou M, 23andMe Research Team, Elson SL, Ideker T, Davis LK, MacKillop J, deWit H, Gustavson DE, Mallard TT, Palmer AA, Sanchez-Roige S. Mol Psychiatry. 2025 Nov. PMID: 41286433 DOI
  • VGLL1 contributes to both the transcriptome and epigenome of the developing trophoblast compartment. Genetics Calderon RI, Sah N, Huang M, Kallol S, Kittle RH, Shaik WB, Abdelbaki A, Chousal JN, Morey R, Bui T, Mitre A, Fogarty NME, Gerri C, Manalo Z, Zheng C, De Hoff P, Home P, Niakan KK, Cook-Andersen H, Fisch KM, Paul S, Soncin F. Proc Natl Acad Sci U S A. 2025 Nov. PMID: 41284866 DOI
  • Whole Genome Sequencing of Sporadic Vestibular Schwannoma Reveals Novel Genetic Changes. GeneticsBehavior Ostrander BT, La Monte O, Li V, Vo V, Kumar A, Telese F, Schwartz MS, Friedman RA. Otol Neurotol. 2025 Nov. PMID: 41249041 DOI
  • Sex-specific transcriptional signatures of oxycodone persist during withdrawal and abstinence in the suprachiasmatic nucleus of heterogeneous stock rats. PARC OpioidsGeneticsBehavior Delorme TC, Sambare S, Williams BR, Gamble MC, Carrette LLG, Solberg Woods LC, Maturin L, Palmer AA, George O, Logan RW. Addict Neurosci. 2025 Oct. PMID: 41477436 DOI
  • L actococcus A phages predict ACLF while Enterococcus B phages predict bacterial infection in decompensated cirrhosis. GeneticsGut–Brain Van Espen L, Brol MJ, Close L, Schierwagen R, Gu W, Keller MI, Balogh B, Fullam A, De Coninck L, Nakamura T, Kuhn M, Bork P, Laleman W, Bajaj JS, Papp M, Schnabl B, Trebicka J, Matthijnssens J, MICROB-PREDICT. JHEP Rep. 2025 Oct. PMID: 41438339 DOI
  • Automated pipeline for operant behavior phenotyping for high-throughput data management, processing, and visualization. PARC OpioidsStimulantsGeneticsGut–BrainBehavior Kim S, Huang Y, Singla U, Hu A, Kalra S, Morgan AA, Sichel B, Othman D, Carrette LLG. NPP Digit Psychiatry Neurosci. 2025 Oct. PMID: 41360967 DOI
  • Single-Nuclei RNA Sequencing Shows the Engagement of PPAR-Delta Target Genes Primarily in Hepatocytes and Cholangiocytes by the Selective PPAR-Delta Agonist Seladelpar. Gut–Brain Yamazaki T, Yang Y, Schöler D, Yukawa-Muto Y, Kouno T, Harberts A, Sakane S, Freund L, Hsu CL, Whisenant TC, Rosenthal SB, Kisseleva T, Cable EE, Schnabl B. PPAR Res. 2025 Oct. PMID: 41180305 DOI
  • Intestinal REG3G Protects Against Gastrointestinal Dysfunction in a Murine Model of Ethanol Intoxication and Burn Injury. AlcoholGut–Brain McMahan RH, Najarro KM, Giesy LE, Evans MR, Schnabl B, Orlicky DJ, Frank DN, Kovacs EJ. Shock. 2025 Oct. PMID: 41166162 DOI
  • Characterizing the Pleiotropic Architecture of Impulsivity and Its Links to Psychopathology and Neurodevelopment. Genetics Mallard TT, Tubbs JD, Jennings M, Zhang Y, Gustavson DE, Grotzinger AD, Westwater ML, Williams CM, Fortgang RG, Elson SL, Fontanillas P, Davis LK, Raznahan A, Tucker-Drob EM, Choi KW, Ge T, Smoller JW, Palmer AA, Sanchez-Roige S. Am J Psychiatry. 2025 Oct. PMID: 41152253 DOI
  • Non-Cirrhotic Steatotic Liver Disease is Associated With Impaired Muscle Function: A Cross-Sectional Study. AlcoholGut–BrainBrain Imaging Henin G, Goffaux A, Declerck S, André-Dumont S, Pendeville E, Valet M, Lejeune T, Dahlqvist G, Loumaye A, Schnabl B, Stärkel P, Lanthier N. JCSM Commun. 2025 Oct. PMID: 41127673 DOI
  • Intestinal REG3 Lectins Protect against Alcoholic Steatohepatitis by Reducing Mucosa-Associated Microbiota and Preventing Bacterial Translocation. AlcoholGut–Brain Wang L, Fouts DE, Stärkel P, Hartmann P, Chen P, Llorente C, DePew J, Moncera K, Ho SB, Brenner DA, Hooper LV, Schnabl B. Cell Host Microbe. 2025 Oct. PMID: 41109221 DOI
  • Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals. Genetics Thorpe HHA, Fontanillas P, Meredith JJ, Jennings MV, Cupertino RB, Pakala SR, 23andMe Research Team, Elson SL, Khokhar JY, Davis LK, Johnson EC, Palmer AA, Sanchez-Roige S. Mol Psychiatry. 2025 Oct. PMID: 41077612 DOI
  • Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge. AlcoholGut–Brain Viebahn GK, Khurana A, Freund L, Chilin-Fuentes D, Jepsen K, Rosenthal SB, Chatterjee S, Ellenrieder V, Hsu CL, Schnabl B, Hartmann P. Am J Physiol Gastrointest Liver Physiol. 2025 Oct. PMID: 41056349 DOI
  • Polycomb repressive complexes 1 and 2 independently and dynamically regulate euchromatin during cerebellar neurodevelopment. GeneticsGut–Brain Parmar A, Srinivasan A, Krockenberger L, Augustine A, Gong O, Bullard AC, Kalra R, Ledvin L, Pilz D, Tawil J, Tea CE, Wang KC, Urso O, Kaube LM, Sun Y, Sasik R, Gaulton KJ, Fisch KM, Ferguson CJ. PLoS Genet. 2025 Sep. PMID: 41021627 DOI
  • Pre-infection cerebral cortex structure predicts murine sepsis outcome. Genetics Gallant RM, Alam S, Venkataraman K, McKenna BS, Khairy K, Ayres JS. PLoS One. 2025 Sep. PMID: 40961093 DOI
  • A Preclinical Alcohol Biobank: Samples from Behaviorally Characterized HS Rats for AUD Research. PARC AlcoholOpioidsStimulantsGeneticsGut–BrainBehavior Doyle MR, Campo P, Dirik S, Balaguer MG, Martinez AR, Kallupi M, Palmer AA, de Guglielmo G. eNeuro. 2025 Sep. PMID: 40940169 DOI
  • Corticotrophin-releasing hormone binding protein in the basolateral amygdala: divergent roles in cocaine and opioid addiction like behaviors. PARC OpioidsStimulantsBehavior Wood CP, Gurha A, Crook C, Martinez A, Dirik S, Moreno C, Vaiyapuri A, Libster A, Telese F, de Guglielmo G. Addict Neurosci. 2025 Aug. PMID: 42395170 DOI
  • YBX1/CD36 positive feedback loop: novel molecular target for MASLD treatment. Jiang Y, Llorente C. Int J Biol Sci. 2025 Aug. PMID: 40959287 DOI
  • Genome-Wide Association Studies of Delay Discounting and Impulsive Personality Traits in Children From the Adolescent Behavior and Cognitive Development Study. GeneticsBehavior Deng WQ, Elsayed M, Belisario KL, Sanchez-Roige S, Palmer AA, MacKillop J. Genes Brain Behav. 2025 Aug. PMID: 40847891 DOI
  • mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity. AlcoholGut–Brain Llorente C, Raya Tonetti F, Bruellman R, Brea R, Pell N, Hartmann P, Maccioni L, Han H, Cabré N, Liu J, Eguileor A, Fondevila MF, Meijnikman AS, Hsu CL, Alghafri A, Zhou R, Gao B, Duan Y, Zhang P, Febbraio MA, Taniguchi K, Newberry RD, Fouts DE, Brenner DA, Stärkel P, Karin M, Schnabl B. Nature. 2025 Aug. PMID: 40836099 DOI
  • Relationship between biological sex and the endocrine stress response following a binge-like dose of alcohol. Alcohol Anthenelli RM, Miles MJ, Hauger R, Schuckit MA, McKenna BS. Alcohol Clin Exp Res (Hoboken). 2025 Aug. PMID: 40748352 DOI
  • The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction. NicotineBehavior Shankar K, Zahedi S, George O. Psychopharmacology (Berl). 2025 Jul. PMID: 40715842 DOI
  • Dysregulation of huntingtin interacting protein networks in human juvenile Huntington's disease brain. GeneticsBehavior Podvin S, Rosenthal B, Mosier C, Wei E, Fisch KM, Hook V. J Huntingtons Dis. 2025 Jul. PMID: 40702852 DOI
  • Genomic structural equation study reveals links between anorexia nervosa and delay discounting and lack of perseverance but not other facets of impulsivity. AlcoholOpioidsNicotineGeneticsBehavior Bianchi SB, Vilar-Ribó L, Palmer AA, Gustavson DE, Sanchez-Roige S. Front Psychiatry. 2025 Jul. PMID: 40687276 DOI
  • Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks. Genetics Wright SN, Leger BS, Rosenthal SB, Liu SN, Jia T, Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Martinez AG, George A, Gileta AF, Han W, Netzley AH, King CP, Lamparelli A, Martin C, St Pierre CL, Wang T, Bimschleger H, Richards J, Ishiwari K, Chen H, Flagel SB, Meyer P, Robinson TE, Solberg Woods LC, Kreisberg JF, Ideker T, Palmer AA. Cell Rep. 2025 Jul. PMID: 40674209 DOI
  • Alcohol, aging, and the gut microbiome: Intersections of immunity, barrier dysfunction, and disease. AlcoholGeneticsGut–Brain Melamed E, Rungratanawanich W, Liangpunsakul S, Maki KA, McCullough RL, Llorente C. Alcohol. 2025 Jul. PMID: 40645301 DOI
  • Cannabidiol mitigates alcohol dependence and withdrawal with neuroprotective effects in the basolateral amygdala and striatum. PARC AlcoholBehavior Dirik S, Doyle MR, Wood CP, Campo P, Martinez AR, Fannon M, Balaguer MG, Seely S, Montoya BA, Cook GMR, Palermo GM, Lin J, Sist MD, Naghshineh PK, Lan Z, Rahman SRMU, Suhandynata R, Schweitzer P, Kallupi M, de Guglielmo G. Neuropsychopharmacology. 2025 Jul. PMID: 40640509 DOI
  • Perinatal fentanyl exposure drives enduring addiction risk and central amygdala gene dysregulation. PARC OpioidsGeneticsBehavior Wood CP, Shin Y, Balaguer MG, Campo P, Dirik S, Montoya BA, Cook GMR, Palermo GM, Naghshineh PK, Morgan A, Rahman SRMU, Palmer AA, Telese F, de Guglielmo G. Neuropharmacology. 2025 Jun. PMID: 40582636 DOI
  • Microbiota in Alcohol-Associated Organ Damage. AlcoholGut–Brain Harberts A, Schnabl B. Am J Pathol. 2025 Jun. PMID: 40513820 DOI
  • Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice. Gut–Brain Li J, Xie S, Chen M, Hong C, Chen Y, Lyu F, Tang N, Chen T, Zhao L, Zou W, Peng H, Bao J, Gu P, Schnabl B, Chen J, Chen P. J Clin Invest. 2025 Jun. PMID: 40478727 DOI
  • Prescription Opioid Medication Survey: A Tool to Collect Deep Phenotypic Data on the Multifactorial Pathways to Opioid Use Disorder in Clinical and Population-Based Cohorts. PARC AlcoholOpioidsNicotineGeneticsBehavior Courchesne-Krak NS, Chandrasekaran AR, Gonzalez J, Bianchi SB, Tran V, Johnson EO, Troiani V, Hettema JM, Stein MB, Coon H, Docherty AR, Berretini WH, MacKillop J, de Wit H, Marienfeld C, Palmer AA, Sanchez-Roige S. Complex Psychiatry. 2025 May. PMID: 40621581 DOI
  • Targeted inhibition of pathobiont virulence factor mitigates alcohol-associated liver disease. AlcoholGeneticsGut–Brain Yang Y, Duan Y, Lang S, Fondevila MF, Schöler D, Harberts A, Cabré N, Chen S, Shao Y, Vervier K, Miyamoto Y, Zhang X, Chu H, Yang L, Tan C, Eckmann L, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Stärkel P, Lawley TD, Schnabl B. Cell Host Microbe. 2025 May. PMID: 40441146 DOI
  • Non-Alcoholic Beer Influences Glucose and Lipid Metabolism and Changes Body Composition in Healthy, Young, Male Adults. AlcoholGut–Brain Kreimeyer H, Sydor S, Buchholz L, Toskal C, Özcürümez M, Schnabl B, Syn WK, Sowa JP, Manka P, Canbay A. Nutrients. 2025 May. PMID: 40431365 DOI
  • Pharmacological and genetic manipulation of glyoxalase-1 (GLO1) does not alter locomotor responses or conditioned place preference induced by cocaine or oxycodone. PARC AlcoholOpioidsStimulantsGeneticsBehavior Alcantara E, Doyle MR, Ortez CA, Ilustrisimo A, Stromberg B, Barkley-Levenson AM, Palmer AA. Pharmacol Biochem Behav. 2025 May. PMID: 40412584 DOI
  • Genome-Wide Association Study of Age-Related Hearing Loss in CFW Mice Identifies Multiple Genes and Loci, Including Prkag2. Genetics Polesskaya O, Boussaty E, Cheng R, Lamonte OA, Zhou TY, Du E, Sanches TM, Nguyen KM, Okamoto M, Palmer AA, Friedman R. J Assoc Res Otolaryngol. 2025 May. PMID: 40399499 DOI
  • Fecal carriage of multidrug-resistant organisms increases the risk of hepatic encephalopathy in patients with cirrhosis: insights from gut microbiota and metabolite features. Gut–Brain Wu PS, Lee PC, Chang TE, Hsieh YC, Huang CW, Lin CH, Huang YL, Lin YT, Huo TI, Schnabl B, Lee KC, Hou MC. Gut Pathog. 2025 May. PMID: 40380209 DOI
  • Activation of intestinal endogenous retroviruses by alcohol exacerbates liver disease. AlcoholGut–Brain Cabré N, Fondevila MF, Wei W, Yamazaki T, Tonetti FR, Eguileor A, Garcia-Carbonell R, Meijnikman AS, Miyamoto Y, Mayo S, Wang Y, Zhang X, Trimbuch T, Lehnardt S, Eckmann L, Fouts DE, Llorente C, Tsukamoto H, Stärkel P, Schnabl B. J Clin Invest. 2025 May. PMID: 40359032 DOI
  • Phylogeographic and genetic network assessment of COVID-19 mitigation protocols on SARS-CoV-2 transmission in university campus residences. Genetics Wertheim JO, Vasylyeva TI, Wood RJ, Cantrell K, Contreras SP, Feldheim A, Goyal R, Havens JL, Knight R, Laurent LC, Moshiri N, Neuhard R, Sathe S, Satterlund A, Scioscia A, Song AY, SEARCH Alliance, Schooley RT, Anderson CM, Martin NK. EBioMedicine. 2025 May. PMID: 40347833 DOI
  • Unlocking the potential of the gut microbiome in liver regeneration: Benefits and mechanistic insights. Gut–Brain Wei W, Schnabl B. Acta Pharm Sin B. 2025 Apr. PMID: 40370569 DOI
  • Associations Between a Genetic Liability Toward Externalizing and Behavioral Outcomes Spanning Toddlerhood Through Early Adulthood in Five Developmental Cohorts. AlcoholGeneticsBehavior Choi M, Poore HE, Brislin SJ, Barr PB, Aliev F, Zellers S, Saunders GRB, Salvatore JE, Vrieze SI, Harden KP, Palmer AA, Raevuori A, Latvala A, COGA Collaborators, Dick DM. J Am Acad Child Adolesc Psychiatry. 2025 Apr. PMID: 40280543 DOI
  • New developments on the effects of alcohol use on immunity, inflammation and organ function: A summary of the 2024 Alcohol and Immunology Research Interest Group (AIRIG) meeting. AlcoholGut–Brain Tschann MM, Vachharajani V, Redmond EM, Hoisington A, Cohen SE, New-Aaron M, Llorente C, Paloczi J, Keating CR, Rungratanawanich W, Burnham EL, Callaci JJ, Raju P, Zhong W, Mandal A, Zimmerly JR, Nuncio ASP, Mandrekar P, McCullough RL, McMahan RH, Wyatt TA, Yeligar SM, Kovacs EJ, Choudhry MA. Alcohol. 2025 Apr. PMID: 40267994 DOI
  • Insertion sequence-mediated phage resistance contributes to attenuated colonization of cytolytic Enterococcus faecalis variants in the gut. AlcoholGut–Brain Fujiki J, Nakamura T, Kreimeyer H, Llorente C, Fouts DE, Schnabl B. Microbiol Spectr. 2025 Apr. PMID: 40231830 DOI
  • Psychiatric genetics in the diverse landscape of Latin American populations. Genetics Bruxel EM, Rovaris DL, Belangero SI, Chavarría-Soley G, Cuellar-Barboza AB, Martínez-Magaña JJ, Nagamatsu ST, Nievergelt CM, Núñez-Ríos DL, Ota VK, Peterson RE, Sloofman LG, Adams AM, Albino E, Alvarado AT, Andrade-Brito D, Arguello-Pascualli PY, Bandeira CE, Bau CHD, Bulik CM, Buxbaum JD, Cappi C, Corral-Frias NS, Corrales A, Corsi-Zuelli F, Crowley JJ, Cupertino RB, da Silva BS, De Almeida SS, De la Hoz JF, Forero DA, Fries GR, Gelernter J, González-Giraldo Y, Grevet EH, Grice DE, Hernández-Garayua A, Hettema JM, Ibáñez A, Ionita-Laza I, Lattig MC, Lima YC, Lin YS, López-León S, Loureiro CM, Martínez-Cerdeño V, Martínez-Levy GA, Melin K, Moreno-De-Luca D, Muniz Carvalho C, Olivares AM, Oliveira VF, Ormond R, Palmer AA, Panzenhagen AC, Passos-Bueno MR, Peng Q, Pérez-Palma E, Prieto ML, Roussos P, Sanchez-Roige S, Santamaría-García H, Shansis FM, Sharp RR, Storch EA, Tavares MEA, Tietz GE, Torres-Hernández BA, Tovo-Rodrigues L, Trelles P, Trujillo-ChiVacuan EM, Velásquez MM, Vera-Urbina F, Voloudakis G, Wegman-Ostrosky T, Zhen-Duan J, Zhou H, Latin American Genomics Consortium, Santoro ML, Nicolini H, Atkinson EG, Giusti-Rodríguez P, Montalvo-Ortiz JL. Nat Genet. 2025 Apr. PMID: 40175716 DOI
  • Metabolic dysfunction-associated steatotic liver disease and the gut microbiome: pathogenic insights and therapeutic innovations. AlcoholGut–Brain Schnabl B, Damman CJ, Carr RM. J Clin Invest. 2025 Apr. PMID: 40166938 DOI
  • Genetic Propensity for Delay Discounting and Educational Attainment in Adults Are Associated With Delay Discounting in Preadolescents: Findings From the Adolescent Brain Cognitive Development Study. GeneticsBehavior Rabinowitz JA, Thomas N, Strickland JC, Meredith JJ, Hung IT, Cupertino RB, Felton JW, Gelino B, Stone B, Maher BS, Dick D, Yi R, Flores-Ocampo V, García-Marín LM, Rentería ME, Palmer AA, Sanchez-Roige S. Genes Brain Behav. 2025 Apr. PMID: 40147852 DOI
  • Faecal Cytolysin is Associated With Worse Survival in Patients With Primary Sclerosing Cholangitis. AlcoholGut–Brain Özdirik B, Berger H, Tonetti FR, Cabré N, Treichel N, Clavel T, Tacke F, Sigal M, Schnabl B. Liver Int. 2025 Apr. PMID: 40083245 DOI
  • Genetic Loci Influencing Cue-Reactivity in Heterogeneous Stock Rats. PARC NicotineGeneticsBehavior King CP, Chitre AS, Leal-Gutiérrez JD, Tripi JA, Netzley AH, Horvath AP, Lamparelli AC, George A, Martin C, St Pierre CL, Missfeldt Sanches T, Bimschleger HV, Gao J, Cheng R, Nguyen KM, Holl KL, Polesskaya O, Ishiwari K, Chen H, Robinson TE, Flagel SB, Solberg Woods LC, Palmer AA, Meyer PJ. Genes Brain Behav. 2025 Apr. PMID: 40049657 DOI
  • RatXcan: A framework for cross-species integration of genome-wide association and gene expression data. PARC Genetics Santhanam N, Sanchez-Roige S, Mi S, Liang Y, Chitre AS, Munro D, Chen D, Gao J, Garcia-Martinez A, George AM, Gileta AF, Han W, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Nyasimi F, St Pierre CL, Sumner S, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Polesskaya O, Saba L, Solberg Woods LC, Palmer AA, Im HK. PLoS Genet. 2025 Mar. PMID: 40163524 DOI
  • Influence of Alcohol on the Intestinal Immune System. AlcoholGut–Brain Kreimeyer H, Llorente C, Schnabl B. Alcohol Res. 2025 Mar. PMID: 40151622 DOI
  • Faecalibacterium prausnitzii Is Associated with Disease Severity in MASLD but Its Supplementation Does Not Improve Diet-Induced Steatohepatitis in Mice. Gut–Brain Münte E, Viebahn G, Khurana A, Fujiki J, Nakamura T, Lang S, Demir M, Schnabl B, Hartmann P. Microorganisms. 2025 Mar. PMID: 40142567 DOI
  • Inhibition of human-HPV hybrid ecDNA enhancers reduces oncogene expression and tumor growth in oropharyngeal cancer. Genetics Nakagawa T, Luebeck J, Zhu K, Lange JT, Sasik R, Phillips C, Sadat S, Javadzadeh S, Yang Q, Monther A, Fassardi S, Wang A, Pestonjamasp K, Rosenthal B, Fisch KM, Mischel P, Bafna V, Califano JA. Nat Commun. 2025 Mar. PMID: 40140353 DOI
  • Bioenergetic-related gene expression in the hippocampus predicts internalizing vs. externalizing behavior in an animal model of temperament. GeneticsBehavior Hebda-Bauer EK, Hagenauer MH, Munro DB, Blandino P, Meng F, Arakawa K, Stead JDH, Chitre AS, Ozel AB, Mohammadi P, Watson SJ, Flagel SB, Li J, Palmer AA, Akil H. Front Mol Neurosci. 2025 Mar. PMID: 40103584 DOI
  • The Farm Animal Genotype-Tissue Expression (FarmGTEx) Project. Genetics Fang L, Teng J, Lin Q, Bai Z, Liu S, Guan D, Li B, Gao Y, Hou Y, Gong M, Pan Z, Yu Y, Clark EL, Smith J, Rawlik K, Xiang R, Chamberlain AJ, Goddard ME, Littlejohn M, Larson G, MacHugh DE, O'Grady JF, Sørensen P, Sahana G, Lund MS, Jiang Z, Pan X, Gong W, Zhang H, He X, Zhang Y, Gao N, He J, Yi G, Liu Y, Tang Z, Zhao P, Zhou Y, Fu L, Wang X, Hao D, Liu L, Chen S, Young RS, Shen X, Xia C, Cheng H, Ma L, Cole JB, Baldwin RL, Li CJ, Van Tassell CP, Rosen BD, Bhowmik N, Lunney J, Liu W, Guan L, Zhao X, Ibeagha-Awemu EM, Luo Y, Lin L, Canela-Xandri O, Derks MFL, Crooijmans RPMA, Gòdia M, Madsen O, Groenen MAM, Koltes JE, Tuggle CK, McCarthy FM, Rocha D, Giuffra E, Amills M, Clop A, Ballester M, Tosser-Klopp G, Li J, Fang C, Fang M, Wang Q, Hou Z, Wang Q, Zhao F, Jiang L, Zhao G, Zhou Z, Zhou R, Liu H, Deng J, Jin L, Li M, Mo D, Liu X, Chen Y, Yuan X, Li J, Zhao S, Zhang Y, Ding X, Sun D, Sun HZ, Li C, Wang Y, Jiang Y, Wu D, Wang W, Fan X, Zhang Q, Li K, Zhang H, Yang N, Hu X, Huang W, Song J, Wu Y, Yang J, Wu W, Kasper C, Liu X, Yu X, Cui L, Zhou X, Kim S, Li W, Im HK, Buckler ES, Ren B, Schatz MC, Li JJ, Palmer AA, Frantz L, Zhou H, Zhang Z, Liu GE, FarmGTEx Consortium. Nat Genet. 2025 Mar. PMID: 40097783 DOI
  • Gram-positive probiotics improves acetaminophen-induced hepatotoxicity by inhibiting leucine and Hippo-YAP pathway. Gut–Brain Gao W, Wang G, Yuan H, Chen Y, Che J, Cheng Z, Chen L, Zhang L, Zhu Y, Liu X, Liu A, Yang Q, Cao P, Qian W, Huang W, Schnabl B, Yang L, Chu H. Cell Biosci. 2025 Mar. PMID: 40055814 DOI
  • Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains. OpioidsGeneticsBehavior Shelton MA, Horan N, Xue X, Maturin L, Eacret D, Michaud J, Singh N, Williams BR, Gamble MC, Seggio JA, Fish MK, Phan BN, Tseng GC, Blendy JA, Solberg Woods LC, Palmer AA, George O, Logan RW, Seney ML. Biol Psychiatry Glob Open Sci. 2025 Feb. PMID: 40248277 DOI
  • Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats. PARC OpioidsGeneticsBehavior Kuhn BN, Cannella N, Chitre AS, Nguyen KH, Cohen K, Chen D, Peng B, Ziegler KS, Lin B, Johnson BB, Missfeldt Sanches T, Crow AD, Lunerti V, Gupta A, Dereschewitz E, Soverchia L, Hopkins JL, Roberts AT, Ubaldi M, Abdulmalek S, Kinen A, Hardiman G, Chung D, Polesskaya O, Solberg Woods LC, Ciccocioppo R, Kalivas PW, Palmer AA. Mol Psychiatry. 2025 Feb. PMID: 40000848 DOI
  • Identification of Plasma Metabolites Responding to Oxycodone Exposure in Rats. PARC OpioidsBehavior Vu T, Godbole S, Carrette LLG, Maturin L, George O, Saba LM, Kechris K. Metabolites. 2025 Feb. PMID: 39997720 DOI
  • Delay discounting data in the Adolescent Brain Cognitive Development (ABCD) study: Modeling and analysis considerations. Behavior Gelino BW, Rabinowitz JA, Maher BS, Felton JW, Yi R, Novak MD, Sanchez-Roige S, Palmer AA, Strickland JC. Exp Clin Psychopharmacol. 2025 Feb. PMID: 39992757 DOI
  • Dissociation of intake and incentive sensitization during intermittent- and continuous-access heroin self-administration in rats. PARC OpioidsStimulantsBehavior Rakowski EA, King CP, Thompson BM, Santos G, Holmes E, Solberg Woods LC, Polesskaya O, Palmer AA, Meyer PJ. Psychopharmacology (Berl). 2025 Feb. PMID: 39979648 DOI
  • Impulsivity facets and substance use involvement: insights from genomic structural equation modeling. Genetics Vilar-Ribó L, Hatoum AS, Grotzinger AD, Mallard TT, 23andMe Research Team, Elson S, Fontanillas P, Palmer AA, Gustavson DE, Sanchez-Roige S. Psychol Med. 2025 Feb. PMID: 39957498 DOI
  • Peroxisome proliferator-activated receptor delta and liver diseases. AlcoholGut–Brain Yamazaki T, Cable EE, Schnabl B. Hepatol Commun. 2025 Feb. PMID: 39899669 DOI
  • A cost-effective, high-throughput, highly accurate genotyping method for outbred populations. PARC Genetics Chen D, Chitre AS, Nguyen KH, Cohen KA, Peng BF, Ziegler KS, Okamoto F, Lin B, Johnson BB, Sanches TM, Cheng R, Polesskaya O, Palmer AA. G3 (Bethesda). 2025 Feb. PMID: 39670731 DOI
  • Role of Intestinal Microbiome in Potentiating Inflammation and Predicting Outcomes in Alcohol-Associated Cirrhosis. AlcoholGut–Brain Støy S, Schnabl B. Gastroenterol Clin North Am. 2025 Jan. PMID: 40348498 DOI
  • Origin, Function, and Implications of Intestinal and Hepatic Macrophages in the Pathogenesis of Alcohol-Associated Liver Disease. AlcoholGut–Brain Hu Y, Schnabl B, Stärkel P. Cells. 2025 Jan. PMID: 39936998 DOI
  • Distinct Behavioral Profiles and Neuronal Correlates of Heroin Vulnerability Versus Resiliency in a Multi-Symptomatic Model of Heroin Use Disorder in Rats. PARC OpioidsGeneticsBehavior Kuhn BN, Cannella N, Crow AD, Lunerti V, Gupta A, Walterhouse SJ, Allen C, Chalhoub RM, Dereschewitz E, Roberts AT, Cockerham M, Beeson A, Nall RW, Palmer AA, Hardiman G, Solberg Woods LC, Chung D, Ciccocioppo R, Kalivas PW. Am J Psychiatry. 2025 Jan. PMID: 39810557 DOI
  • Modulating the microbiome in chronic liver diseases - current evidence on the role of fecal microbiota transplantation. AlcoholGut–Brain Saha S, Schnabl B. Expert Rev Gastroenterol Hepatol. 2025 Jan. PMID: 39760535 DOI
  • Author Correction: Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. Genetics Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2025 Jan. PMID: 39643700 DOI

2024

  • Gut microbiota in treating inflammatory digestive diseases: Current challenges and therapeutic opportunities. Gut–Brain Shi Y, Chen Z, Fang T, Chen X, Deng Y, Qin H, Lian M, Shen J, Zong Y, Chu H, Hoebinger C, Guo H, Yuan Z, Zheng J, Zhou Y, Pan Y, Mendes BG, Lang S, Hendrikx T, Zeng S, Cao H, Yang L, Chen L, Chen P, Dai L, Wang H, Yin S, Zhu S, Ma X, Schnabl B, Chen H, Duan Y. Imeta. 2024 Dec. PMID: 40027479 DOI
  • Induction of MASH in three-dimensional bioprinted human liver tissue. AlcoholGut–Brain Joshi V, Carter D, Chen AE, Murphy K, Higgins JW, Gurel M, Chilin Fuentes D, Rosenthal SB, Fisch KM, Kisseleva T, Brenner DA. PLoS One. 2024 Dec. PMID: 39775546 DOI
  • Genomic structural equation modeling of reward-related traits: exploring the genetic factor structure and its relationship with psychopathology. AlcoholGenetics Cardoso Melo D, Trindade Pons V, Mallard TT, Sanchez-Roige S, Palmer AA, Xie T, Snieder H, Hartman CA. Psychiatry Res. 2024 Dec. PMID: 39721098 DOI
  • Associations Between Social Determinants of Health and Opioid-Use Disorder Among Chronic Pain Patients From a Multi-Institutional Dataset. Opioids Do VM, Simpson S, Fisch KM, Gabriel RA. Anesth Analg. 2024 Dec. PMID: 39715077 DOI
  • The Association of Social Determinants of Health With Reported Daily Pain Scores Among Patients With a History of Chronic Pain Using the "All of Us" Research Program. Park BH, Macias AA, Fisch KM, Simpson S, Chen J, Gabriel RA. Anesth Analg. 2024 Dec. PMID: 39661558 DOI
  • Author Correction: Hepatic immune regulation and sex disparities. Burra P, Zanetto A, Schnabl B, Reiberger T, Montano-Loza AJ, Asselta R, Karlsen TH, Tacke F. Nat Rev Gastroenterol Hepatol. 2024 Dec. PMID: 39390290 DOI
  • Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. AlcoholGut–Brain Kreimeyer H, Gonzalez CG, Fondevila MF, Hsu CL, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez DJ, Schnabl B. Gut. 2024 Dec. PMID: 39033024 DOI
  • Multiomic Network Analysis Identifies Dysregulated Neurobiological Pathways in Opioid Addiction. OpioidsGenetics Sullivan KA, Kainer D, Lane M, Cashman M, Miller JI, Garvin MR, Townsend A, Quach BC, Willis C, Kruse P, Gaddis NC, Mathur R, Corradin O, Maher BS, Scacheri PC, Sanchez-Roige S, Palmer AA, Troiani V, Chesler EJ, Kember RL, Kranzler HR, Justice AC, Xu K, Aouizerat BE, Hancock DB, Johnson EO, Jacobson DA, VA Million Veteran Program. Biol Psychiatry. 2024 Nov. PMID: 39615775 DOI
  • Multimodal analysis of RNA sequencing data powers discovery of complex trait genetics. Genetics Munro D, Ehsan N, Esmaeili-Fard SM, Gusev A, Palmer AA, Mohammadi P. Nat Commun. 2024 Nov. PMID: 39613793 DOI
  • Towards more consistent models and consensual terminology in preclinical research for steatotic liver disease. AlcoholGut–Brain Meijnikman AS, Fondevila MF, Arrese M, Kisseleva T, Bataller R, Schnabl B. J Hepatol. 2024 Nov. PMID: 39581500 DOI
  • Noninvasive Monitoring of Steatotic Liver Disease in Western Diet-Fed Obese Mice Using Automated Ultrasound and Shear Wave Elastography. Gut–BrainBrain Imaging Czernuszewicz TJ, Wang Y, Jiang L, Kim K, Mikulski Z, Aji AM, Rojas JD, Gessner RC, Schnabl B. Liver Int. 2024 Nov. PMID: 39523997 DOI
  • Large-scale characterization of cocaine addiction-like behaviors reveals that escalation of intake, aversion-resistant responding, and breaking-points are highly correlated measures of the same construct. PARC StimulantsGeneticsBehavior de Guglielmo G, Carrette L, Kallupi M, Brennan M, Boomhower B, Maturin L, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Martinez AR, Velarde N, Othman D, Sichel B, Ramborger J, Lau J, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Bonnet-Zahedi S, Sneddon EA, Avelar A, Plasil SL, Mosquera J, Crook C, Chun L, Vang A, Milan KK, Schweitzer P, Lin B, Peng B, Chitre AS, Polesskaya O, Solberg Woods LC, Palmer AA, George O. Elife. 2024 Nov. PMID: 39484794 DOI
  • Y and mitochondrial chromosomes in the heterogeneous stock rat population. PARC GeneticsGut–BrainBehavior Okamoto F, Chitre AS, Missfeldt Sanches T, Chen D, Munro D, Aron AT, Beeson A, Bimschleger HV, Eid M, Garcia Martinez AG, Han W, Holl K, Jackson T, Johnson BB, King CP, Kuhn BN, Lamparelli AC, Netzley AH, Nguyen KH, Peng BF, Tripi JA, Wang T, Ziegler KS, Adams DJ, Baud A, Carrette LLG, Chen H, de Guglielmo G, Dorrestein P, George O, Ishiwari K, Jablonski MM, Jhou TC, Kallupi M, Knight R, Meyer PJ, Solberg Woods LC, Polesskaya O, Palmer AA. G3 (Bethesda). 2024 Nov. PMID: 39250761 DOI
  • Prevalence of steatotic liver disease, advanced fibrosis and cirrhosis among community-dwelling overweight and obese individuals in the USA. AlcoholGut–BrainBrain Imaging Yang AH, Tincopa MA, Tavaglione F, Ajmera VH, Richards LM, Amangurbanova M, Butcher C, Hernandez C, Madamba E, Singh S, Bettencourt R, Schnabl B, Sirlin CB, Loomba R. Gut. 2024 Nov. PMID: 39117370 DOI
  • Goblet cells: guardians of gut immunity and their role in gastrointestinal diseases. Gut–Brain Tonetti FR, Eguileor A, Llorente C. eGastroenterology. 2024 Oct. PMID: 39524932 DOI
  • An emerging multi-omic understanding of the genetics of opioid addiction. OpioidsGenetics Johnson EO, Fisher HS, Sullivan KA, Corradin O, Sanchez-Roige S, Gaddis NC, Sami YN, Townsend A, Teixeira Prates E, Pavicic M, Kruse P, Chesler EJ, Palmer AA, Troiani V, Bubier JA, Jacobson DA, Maher BS. J Clin Invest. 2024 Oct. PMID: 39403933 DOI
  • PAGER: A novel genotype encoding strategy for modeling deviations from additivity in complex trait association studies. Genetics Freda PJ, Ghosh A, Bhandary P, Matsumoto N, Chitre AS, Zhou J, Hall MA, Palmer AA, Obafemi-Ajayi T, Moore JH. BioData Min. 2024 Oct. PMID: 39394173 DOI
  • Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis. AlcoholGut–Brain Hsu CL, Wang L, Maestri E, Jacob AR, Do WL, Mayo S, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Stärkel P, Bataller R, Investigators A, Wang XW, Schnabl B, New Collective Author. Hepatology. 2024 Sep. PMID: 39325984 DOI
  • IL-22 resolves MASLD via enterocyte STAT3 restoration of diet-perturbed intestinal homeostasis. Gut–Brain Zhang P, Liu J, Lee A, Tsaur I, Ohira M, Duong V, Vo N, Watari K, Su H, Kim JY, Gu L, Zhu M, Shalapour S, Hosseini M, Bandyopadhyay G, Zeng S, Llorente C, Zhao HN, Lamichhane S, Mohan S, Dorrestein PC, Olefsky JM, Schnabl B, Soroosh P, Karin M. Cell Metab. 2024 Sep. PMID: 39317186 DOI
  • Do tobacco regulatory and economic factors influence smoking cessation outcomes? A post-hoc analysis of the multinational EAGLES randomised controlled trial. Nicotine Daniel B, Lawrence DE, McKenna BS, Saccone P, McRae T, Evins AE, Anthenelli RM. BMJ Open. 2024 Sep. PMID: 39306350 DOI
  • Response to Letter to the Editor: Comment on Article: Aspirin resistance in pregnancy is associated with reduced interleukin-2 concentration in maternal serum. Fisch KM. Pregnancy Hypertens. 2024 Sep. PMID: 39305542 DOI
  • Publisher Correction: Hazardous drinking and alcohol use disorders. Alcohol MacKillop J, Agabio R, Feldstein Ewing SW, Heilig M, Kelly JF, Leggio L, Lingford-Hughes A, Palmer AA, Parry CD, Ray L, Rehm J. Nat Rev Dis Primers. 2024 Sep. PMID: 39304664 DOI
  • Hepatic immune regulation and sex disparities. GeneticsGut–Brain Burra P, Zanetto A, Schnabl B, Reiberger T, Montano-Loza AJ, Asselta R, Karlsen TH, Tacke F. Nat Rev Gastroenterol Hepatol. 2024 Sep. PMID: 39237606 DOI
  • Do polygenic indices capture "direct" effects on child externalizing behavior problems? Within-family analyses in two longitudinal birth cohorts. GeneticsBehavior Tanksley PT, Brislin SJ, Wertz J, de Vlaming R, Courchesne-Krak NS, Mallard TT, Raffington LL, Karlsson Linnér R, Koellinger P, Palmer AA, Sanchez-Roige S, Waldman ID, Dick D, Moffitt TE, Caspi A, Harden KP. Clin Psychol Sci. 2024 Aug. PMID: 40110515 DOI
  • High quality, high throughput, and low-cost simultaneous video recording of 60 animals in operant chambers using PiRATeMC. PARC Behavior Ramborger J, Kalra S, Mosquera J, Smith ACW, George O. J Neurosci Methods. 2024 Aug. PMID: 39222797 DOI
  • Fecal gelatinase does not predict mortality in patients with alcohol-associated hepatitis. AlcoholGut–Brain Yang Y, Hartmann P, Schnabl B. Microb Cell. 2024 Aug. PMID: 39206205 DOI
  • RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection. Huang M, Mark A, Pham J, Vera K, Saravia-Butler AM, Beheshti A, Jiang Q, Fisch KM. PLoS One. 2024 Aug. PMID: 39178184 DOI
  • Genome-wide association study of delay discounting in Heterogeneous Stock rats. PARC GeneticsBehavior Lara MK, Chitre AS, Chen D, Johnson BB, Nguyen KM, Cohen KA, Muckadam SA, Lin B, Ziegler S, Beeson A, Sanches TM, Solberg Woods LC, Polesskaya O, Palmer AA, Mitchell SH. Genes Brain Behav. 2024 Aug. PMID: 39119916 DOI
  • Gut mycobiome alterations and implications for liver diseases. Gut–Brain Zeng S, Schnabl B. PLoS Pathog. 2024 Aug. PMID: 39116092 DOI
  • Gut Bacteria in Alcohol-Associated Liver Disease. AlcoholGut–Brain Yang Y, Schnabl B. Clin Liver Dis. 2024 Jul. PMID: 39362714 DOI
  • Relationship between updated MELD and prognosis in alcohol-associated hepatitis: Opportunities for more efficient trial design. AlcoholGut–Brain Al-Karaghouli M, Ventura-Cots M, Wong YJ, Genesca J, Bosques F, Brown RS, Mathurin P, Louvet A, Shawcross D, Vargas V, Verna EC, Schnabl B, Caballeria J, Shah VJ, Kamath PS, Lucey MR, Garcia-Tsao G, Bataller R, Abraldes JG. Hepatol Commun. 2024 Jul. PMID: 39082963 DOI
  • Comparative single-cell transcriptional and proteomic atlas of clinical-grade injectable mesenchymal source tissues. Ruoss S, Nasamran CA, Ball ST, Chen JL, Halter KN, Bruno KA, Whisenant TC, Parekh JN, Dorn SN, Esparza MC, Bremner SN, Fisch KM, Engler AJ, Ward SR. Sci Adv. 2024 Jul. PMID: 38996032 DOI
  • PI3Kγ inhibition circumvents inflammation and vascular leak in SARS-CoV-2 and other infections. Shepard RM, Ghebremedhin A, Pratumchai I, Robinson SR, Betts C, Hu J, Sasik R, Fisch KM, Zak J, Chen H, Paradise M, Rivera J, Amjad M, Uchiyama S, Seo H, Campos AD, Dayao DA, Tzipori S, Piedra-Mora C, Das S, Hasteh F, Russo H, Sun X, Xu L, Crotty Alexander LE, Duran JM, Odish M, Pretorius V, Kirchberger NC, Chin SM, Von Schalscha T, Cheresh D, Morrey JD, Alargova R, O'Connell B, Martinot TA, Patel SP, Nizet V, Martinot AJ, Coussens LM, Teijaro JR, Varner JA. Sci Transl Med. 2024 Jul. PMID: 38959328 DOI
  • Rare and common variants associated with alcohol consumption identify a conserved molecular network. AlcoholGeneticsGut–BrainBehavior Leger BS, Meredith JJ, Ideker T, Sanchez-Roige S, Palmer AA. Alcohol Clin Exp Res (Hoboken). 2024 Jun. PMID: 39031522 DOI
  • The genomic landscape of Ménière's disease: a path to endolymphatic hydrops. Genetics Fisch KM, Rosenthal SB, Mark A, Sasik R, Nasamran CA, Clifford R, Derebery MJ, Boussaty E, Jepsen K, Harris J, Friedman RA. BMC Genomics. 2024 Jun. PMID: 38943082 DOI
  • The single-cell opioid responses in the context of HIV (SCORCH) consortium. OpioidsGenetics Ament SA, Campbell RR, Lobo MK, Receveur JP, Agrawal K, Borjabad A, Byrareddy SN, Chang L, Clarke D, Emani P, Gabuzda D, Gaulton KJ, Giglio M, Giorgi FM, Gok B, Guda C, Hadas E, Herb BR, Hu W, Huttner A, Ishmam MR, Jacobs MM, Kelschenbach J, Kim DW, Lee C, Liu S, Liu X, Madras BK, Mahurkar AA, Mash DC, Mukamel EA, Niu M, O'Connor RM, Pagan CM, Pang APS, Pillai P, Repunte-Canonigo V, Ruzicka WB, Stanley J, Tickle T, Tsai SA, Wang A, Wills L, Wilson AM, Wright SN, Xu S, Yang J, Zand M, Zhang L, Zhang J, Akbarian S, Buch S, Cheng CS, Corley MJ, Fox HS, Gerstein M, Gummuluru S, Heiman M, Ho YC, Kellis M, Kenny PJ, Kluger Y, Milner TA, Moore DJ, Morgello S, Ndhlovu LC, Rana TM, Sanna PP, Satterlee JS, Sestan N, Spector SA, Spudich S, Tilgner HU, Volsky DJ, White OR, Williams DW, Zeng H. Mol Psychiatry. 2024 Jun. PMID: 38879719 DOI
  • Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations. PARC GeneticsGut–BrainBehavior Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA, Sanchez-Roige S. Neuropsychopharmacology. 2024 Jun. PMID: 38858598 DOI
  • Aspirin resistance in pregnancy is associated with reduced interleukin-2 (IL-2) concentrations in maternal serum: Implications for aspirin prophylaxis for preeclampsia. Hernandez F, Chavez H, Goemans SL, Kirakosyan Y, Luevano CD, Canfield D, Laurent LC, Jacobs M, Woelkers D, Tarsa M, Gyamfi-Bannerman C, Fisch KM. Pregnancy Hypertens. 2024 Jun. PMID: 38851168 DOI
  • Comprehensive next-generation sequencing identifies novel putative pathogenic or likely pathogenic germline variants in patients with concurrent tubo-ovarian and endometrial serous and endometrioid carcinomas or precursors. Genetics Aisagbonhi O, Ghlichloo I, Hong DS, Roma A, Fadare O, Eskander R, Saenz C, Fisch KM, Song W. Gynecol Oncol. 2024 Jun. PMID: 38833993 DOI
  • Endogenous ethanol production in health and disease. AlcoholGut–Brain Meijnikman AS, Nieuwdorp M, Schnabl B. Nat Rev Gastroenterol Hepatol. 2024 Jun. PMID: 38831008 DOI
  • Commentary on the gut microbiome in alcohol use disorder and alcohol-associated liver disease. AlcoholGut–Brain Llorente C. Alcohol Clin Exp Res (Hoboken). 2024 Jun. PMID: 38825713 DOI
  • The Imperative for Innovative Enteric Nervous System-Intestinal Organoid Co-Culture Models: Transforming GI Disease Modeling and Treatment. Gut–Brain Llorente C. Cells. 2024 May. PMID: 38786042 DOI
  • Isolation of Myenteric and Submucosal Plexus from Mouse Gastrointestinal Tract and Subsequent Co-Culture with Small Intestinal Organoids. Gut–Brain Llorente C. Cells. 2024 May. PMID: 38786037 DOI
  • Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types. Gut–BrainBehavior Faget L, Oriol L, Lee WC, Zell V, Sargent C, Flores A, Hollon NG, Ramanathan D, Hnasko TS. Nat Commun. 2024 May. PMID: 38762463 DOI
  • Gut-liver axis: Recent concepts in pathophysiology in alcohol-associated liver disease. AlcoholGut–Brain Raya Tonetti F, Eguileor A, Mrdjen M, Pathak V, Travers J, Nagy LE, Llorente C. Hepatology. 2024 May. PMID: 38691396 DOI
  • Cord Blood Adductomics Reveals Oxidative Stress Exposure Pathways of Bronchopulmonary Dysplasia. Lin ET, Bae Y, Birkett R, Sharma AM, Zhang R, Fisch KM, Funk W, Mestan KK. Antioxidants (Basel). 2024 Apr. PMID: 38671941 DOI
  • TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Gut–Brain Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. Cell Metab. 2024 Apr. PMID: 38670107 DOI
  • Acute nicotine activates orectic and inhibits anorectic brain regions in rats exposed to chronic nicotine. PARC NicotineBehavior Shankar K, Bonnet-Zahedi S, Milan K, D'argence AR, Sneddon E, Qiao R, Chonwattangul S, Carrette LLG, Kallupi M, George O. Neuropharmacology. 2024 Apr. PMID: 38648925 DOI
  • Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes. PARC NicotineGenetics Toikumo S, Jennings MV, Pham BK, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Xu H, Hatoum AS, Johnson EC, Pazdernik VK, Jinwala Z, Pakala SR, Leger BS, Niarchou M, Ehinmowo M, Penn Medicine BioBank, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. Nat Hum Behav. 2024 Apr. PMID: 38632388 DOI
  • A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals. AlcoholGenetics Jennings MV, Martínez-Magaña JJ, Courchesne-Krak NS, Cupertino RB, Vilar-Ribó L, Bianchi SB, Hatoum AS, Atkinson EG, Giusti-Rodriguez P, Montalvo-Ortiz JL, Gelernter J, Artigas MS, 23andMe, Inc. Research Team, Elson SL, Edenberg HJ, Fontanillas P, Palmer AA, Sanchez-Roige S. EBioMedicine. 2024 Apr. PMID: 38580523 DOI
  • Chronic villitis as a distinctive feature of placental injury in maternal SARS-CoV-2 infection. Gut–Brain Gabby LC, Jones CK, McIntyre BB, Manalo Z, Meads M, Pizzo DP, Diaz-Vigil J, Soncin F, Fisch KM, Ramos GA, Jacobs MB, Parast MM. Am J Obstet Gynecol. 2024 Apr. PMID: 38580043 DOI
  • A revamped rat reference genome improves the discovery of genetic diversity in laboratory rats. PARC Genetics de Jong TV, Pan Y, Rastas P, Munro D, Tutaj M, Akil H, Benner C, Chen D, Chitre AS, Chow W, Colonna V, Dalgard CL, Demos WM, Doris PA, Garrison E, Geurts AM, Gunturkun HM, Guryev V, Hourlier T, Howe K, Huang J, Kalbfleisch T, Kim P, Li L, Mahaffey S, Martin FJ, Mohammadi P, Ozel AB, Polesskaya O, Pravenec M, Prins P, Sebat J, Smith JR, Solberg Woods LC, Tabakoff B, Tracey A, Uliano-Silva M, Villani F, Wang H, Sharp BM, Telese F, Jiang Z, Saba L, Wang X, Murphy TD, Palmer AA, Kwitek AE, Dwinell MR, Williams RW, Li JZ, Chen H. Cell Genom. 2024 Mar. PMID: 38537634 DOI
  • Interaction models matter: an efficient, flexible computational framework for model-specific investigation of epistasis. Genetics Batista S, Madar VS, Freda PJ, Bhandary P, Ghosh A, Matsumoto N, Chitre AS, Palmer AA, Moore JH. BioData Min. 2024 Feb. PMID: 38419006 DOI
  • PPAR Agonists in Primary Biliary Cholangitis. Schnabl B. N Engl J Med. 2024 Feb. PMID: 38381666 DOI
  • Sex differences in alcohol's effects on fronto-amygdalar functional connectivity during processing of emotional stimuli. AlcoholBrain Imaging McKenna BS, Anthenelli RM, Schuckit MA. Alcohol Clin Exp Res (Hoboken). 2024 Feb. PMID: 38379361 DOI
  • Environmental enrichment promotes adaptive responding during tests of behavioral regulation in male heterogeneous stock rats. PARC StimulantsGeneticsBehavior Ishiwari K, King CP, Martin CD, Tripi JA, George AM, Lamparelli AC, Chitre AS, Polesskaya O, Richards JB, Solberg Woods LC, Gancarz AM, Palmer AA, Dietz DM, Mitchell SH, Meyer PJ. Sci Rep. 2024 Feb. PMID: 38378969 DOI
  • Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. AlcoholGut–Brain Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B, AlcHepNet Investigators. Hepatology. 2024 Feb. PMID: 38377466 DOI
  • The role of the microbiome in liver disease. AlcoholGut–Brain Schöler D, Schnabl B. Curr Opin Gastroenterol. 2024 Feb. PMID: 38362864 DOI
  • Nuclear morphology is shaped by loop-extrusion programs. Patta I, Zand M, Lee L, Mishra S, Bortnick A, Lu H, Prusty A, McArdle S, Mikulski Z, Wang HY, Cheng CS, Fisch KM, Hu M, Murre C. Nature. 2024 Feb. PMID: 38355805 DOI
  • Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease. AlcoholGut–Brain Viebahn G, Hartmann P, Lang S, Demir M, Zhang X, Fouts DE, Stärkel P, Schnabl B. Gut Microbes. 2024 Feb. PMID: 38298161 DOI
  • A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder. Alcohol Mason BJ, Estey D, Roberts A, de Guglielmo G, George O, Light J, Stoolmiller M, Quello S, Skinner M, Shadan F, Begovic A, Kyle MC, Harris RA. Neurobiol Stress. 2024 Jan. PMID: 38292518 DOI
  • Malignant A-to-I RNA editing by ADAR1 drives T cell acute lymphoblastic leukemia relapse via attenuating dsRNA sensing. Behavior Rivera M, Zhang H, Pham J, Isquith J, Zhou QJ, Balaian L, Sasik R, Enlund S, Mark A, Ma W, Holm F, Fisch KM, Kuo DJ, Jamieson C, Jiang Q. Cell Rep. 2024 Jan. PMID: 38265938 DOI
  • Lipopolysaccharide-induced chronic inflammation increases female serum gonadotropins and shifts the pituitary transcriptomic landscape. Garcia C, Velez LM, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch KM, Lawson MA, Duleba AJ, Seldin MM, Nicholas DA. Front Endocrinol (Lausanne). 2024 Jan. PMID: 38260148 DOI
  • Genetic architecture distinguishes tinnitus from hearing loss. Genetics Clifford RE, Maihofer AX, Chatzinakos C, Coleman JRI, Daskalakis NP, Gasperi M, Hogan K, Mikita EA, Stein MB, Tcheandjieu C, Telese F, Zuo Y, Ryan AF, Nievergelt CM. Nat Commun. 2024 Jan. PMID: 38242899 DOI

2023

  • Microbial Players in Primary Sclerosing Cholangitis: Current Evidence and Concepts. GeneticsGut–Brain Özdirik B, Schnabl B. Cell Mol Gastroenterol Hepatol. 2023 Dec. PMID: 38109970 DOI
  • Genomic surveillance reveals dynamic shifts in the connectivity of COVID-19 epidemics. Genetics Matteson NL, Hassler GW, Kurzban E, Schwab MA, Perkins SA, Gangavarapu K, Levy JI, Parker E, Pride D, Hakim A, De Hoff P, Cheung W, Castro-Martinez A, Rivera A, Veder A, Rivera A, Wauer C, Holmes J, Wilson J, Ngo SN, Plascencia A, Lawrence ES, Smoot EW, Eisner ER, Tsai R, Chacón M, Baer NA, Seaver P, Salido RA, Aigner S, Ngo TT, Barber T, Ostrander T, Fielding-Miller R, Simmons EH, Zazueta OE, Serafin-Higuera I, Sanchez-Alavez M, Moreno-Camacho JL, García-Gil A, Murphy Schafer AR, McDonald E, Corrigan J, Malone JD, Stous S, Shah S, Moshiri N, Weiss A, Anderson C, Aceves CM, Spencer EG, Hufbauer EC, Lee JJ, King AJ, Ramesh KS, Nguyen KN, Saucedo K, Robles-Sikisaka R, Fisch KM, Gonias SL, Birmingham A, McDonald D, Karthikeyan S, Martin NK, Schooley RT, Negrete AJ, Reyna HJ, Chavez JR, Garcia ML, Cornejo-Bravo JM, Becker D, Isaksson M, Washington NL, Lee W, Garfein RS, Luna-Ruiz Esparza MA, Alcántar-Fernández J, Henson B, Jepsen K, Olivares-Flores B, Barrera-Badillo G, Lopez-Martínez I, Ramírez-González JE, Flores-León R, Kingsmore SF, Sanders A, Pradenas A, White B, Matthews G, Hale M, McLawhon RW, Reed SL, Winbush T, McHardy IH, Fielding RA, Nicholson L, Quigley MM, Harding A, Mendoza A, Bakhtar O, Browne SH, Olivas Flores J, Rincon Rodríguez DG, Gonzalez Ibarra M, Robles Ibarra LC, Arellano Vera BJ, Gonzalez Garcia J, Harvey-Vera A, Knight R, Laurent LC, Yeo GW, Wertheim JO, Ji X, Worobey M, Suchard MA, Andersen KG, Campos-Romero A, Wohl S, Zeller M. Cell. 2023 Dec. PMID: 38101407 DOI
  • Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release. GeneticsBehavior Warlow SM, Singhal SM, Hollon NG, Faget L, Dowlat DS, Zell V, Hunker AC, Zweifel LS, Hnasko TS. Neuron. 2023 Dec. PMID: 38086374 DOI
  • Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism. Gut–Brain Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y, Ma Q, Chen P. Cell Host Microbe. 2023 Dec. PMID: 38056458 DOI
  • Executive Function and Impulsivity Predict Distinct Genetic Variance in Internalizing Problems, Externalizing Problems, Thought Disorders, and Compulsive Disorders: A Genomic Structural Equation Modeling Study. PARC GeneticsBehavior Gustavson DE, Morrison CL, Mallard TT, Jennings MV, Fontanillas P, Elson SL, Palmer AA, Friedman NP, Sanchez-Roige S. Clin Psychol Sci. 2023 Nov. PMID: 39323941 DOI
  • Genome-Wide Association Study of Chronic Dizziness in the Elderly Identifies Loci Implicating MLLT10, BPTF, LINC01224, and ROS1. Genetics Clifford R, Munro D, Dochtermann D, Devineni P, Pyarajan S, Million Veteran Program, Telese F, Palmer AA, Mohammadi P, Friedman R. J Assoc Res Otolaryngol. 2023 Nov. PMID: 38036714 DOI
  • Resident microbes shape the vaginal epithelial glycan landscape. Gut–Brain Agarwal K, Choudhury B, Robinson LS, Morrill SR, Bouchibiti Y, Chilin-Fuentes D, Rosenthal SB, Fisch KM, Peipert JF, Lebrilla CB, Allsworth JE, Lewis AL, Lewis WG. Sci Transl Med. 2023 Nov. PMID: 38019934 DOI
  • Development of a Quantitative PCR Method for Detecting Enterococcus faecalis Cytolysin in Human Stool Samples. AlcoholGut–Brain Cabré N, Yang Y, Wang Y, Schnabl B. Methods Protoc. 2023 Nov. PMID: 37987354 DOI
  • Defining the relationship of salivary gland malignancies to novel cell subpopulations in human salivary glands using single nucleus RNA-sequencing. Nakagawa T, Santos J, Nasamran CA, Sen P, Sadat S, Monther A, Bendik J, Ebisumoto K, Hu J, Preissl S, Guo T, Vavinskaya V, Fisch KM, Califano JA. Int J Cancer. 2023 Nov. PMID: 37971144 DOI
  • Acute nicotine intake increases feeding behavior through decreasing glucagon signaling in dependent male and female rats. NicotineBehavior Shankar K, Ramborger J, Bonnet-Zahedi S, Carrette LLG, George O. Horm Behav. 2023 Nov. PMID: 37926623 DOI
  • Author Correction: Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. PARC StimulantsGeneticsBehavior Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. Nat Neurosci. 2023 Nov. PMID: 37845545 DOI
  • Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans. GeneticsGut–Brain Guilbaud A, Ghanegolmohammadi F, Wang Y, Leng J, Kreymerman A, Gamboa Varela J, Garbern J, Elwell H, Cao F, Ricci-Blair EM, Liang C, Balamkundu S, Vidoudez C, DeMott MS, Bedi K, Margulies KB, Bennett DA, Palmer AA, Barkley-Levenson A, Lee RT, Dedon PC. Nucleic Acids Res. 2023 Nov. PMID: 37843128 DOI
  • High placental expression of FLT1, LEP, PHYHIP and IL3RA - In persons of African ancestry with severe preeclampsia. Aisagbonhi O, Bui T, Nasamran CA, St Louis H, Pizzo D, Meads M, Mulholland M, Magallanes C, Lamale-Smith L, Laurent LC, Morey R, Jacobs MB, Fisch KM, Horii M. Placenta. 2023 Oct. PMID: 37949031 DOI
  • Combining varenicline preloading with Acceptance and Commitment Therapy (ACT) in persons with serious mental illness who smoke: The randomized ACTSLow pilot feasibility trial. Anthenelli RM, McKenna BS, Giannini J, Attaluri SV, Rubin M, O'Crowley E, Miller S, Heffner JL. Drug Alcohol Depend. 2023 Oct. PMID: 37931328 DOI
  • Catechol-O-Methyltransferase inhibition and alcohol use disorder: Evaluating the efficacy of tolcapone in ethanol-dependent rats. PARC AlcoholBehavior Doyle MR, Dirik S, Martinez AR, Hughes TE, Iyer MR, Sneddon EA, Seo H, Cohen SM, de Guglielmo G. Neuropharmacology. 2023 Oct. PMID: 37858886 DOI
  • Single-nucleus genomics in outbred rats with divergent cocaine addiction-like behaviors reveals changes in amygdala GABAergic inhibition. PARC StimulantsGeneticsBehavior Zhou JL, de Guglielmo G, Ho AJ, Kallupi M, Pokhrel N, Li HR, Chitre AS, Munro D, Mohammadi P, Carrette LLG, George O, Palmer AA, McVicker G, Telese F. Nat Neurosci. 2023 Oct. PMID: 37798411 DOI
  • Phage therapy: Targeting intestinal bacterial microbiota for the treatment of liver diseases. Gut–Brain Fujiki J, Schnabl B. JHEP Rep. 2023 Sep. PMID: 37965159 DOI
  • Directed evolution unlocks oxygen reactivity for a nicotine-degrading flavoenzyme. NicotineGeneticsBehavior Dulchavsky M, Mitra R, Wu K, Li J, Boer K, Liu X, Zhang Z, Vasquez C, Clark CT, Funckes K, Shankar K, Bonnet-Zahedi S, Siddiq M, Sepulveda Y, Suhandynata RT, Momper JD, Calabrese AN, George O, Stull F, Bardwell JCA. Nat Chem Biol. 2023 Sep. PMID: 37770699 DOI
  • Discrimination of cell-intrinsic and environment-dependent effects of natural genetic variation on Kupffer cell epigenomes and transcriptomes. Genetics Bennett H, Troutman TD, Zhou E, Spann NJ, Link VM, Seidman JS, Nickl CK, Abe Y, Sakai M, Pasillas MP, Marlman JM, Guzman C, Hosseini M, Schnabl B, Glass CK. Nat Immunol. 2023 Sep. PMID: 37735593 DOI
  • Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics. Genetics Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Karlsson Linnér R. Behav Genet. 2023 Sep. PMID: 37713023 DOI
  • A Network Landscape of HPVOPC Reveals Methylation Alterations as Significant Drivers of Gene Expression via an Immune-Mediated GPCR Signal. Qualliotine JR, Nakagawa T, Rosenthal SB, Sadat S, Ballesteros-Merino C, Xu G, Mark A, Nasamran A, Gutkind JS, Fisch KM, Guo T, Fox BA, Khan Z, Molinolo AA, Califano JA. Cancers (Basel). 2023 Sep. PMID: 37686653 DOI
  • The arginine methyltransferase PRMT5 promotes mucosal defense in the intestine. Gut–Brain Hernandez JE, Llorente C, Ma S, Miyamoto KT, Sinha S, Steele S, Xiao Z, Lai CJ, Zuniga EI, Ghosh P, Schnabl B, Huang WJM. Life Sci Alliance. 2023 Sep. PMID: 37666668 DOI
  • A multivariate approach to understanding the genetic overlap between externalizing phenotypes and substance use disorders. Genetics Poore HE, Hatoum A, Mallard TT, Sanchez-Roige S, Waldman ID, Palmer AA, Harden KP, Barr PB, Dick DM. Addict Biol. 2023 Sep. PMID: 37644899 DOI
  • Chronic administration of a norepinephrine antagonist prevents and partially reverses escalation of cocaine self-administration. PARC StimulantsBehavior Beldjoud H, Avelar A, de Guglielmo G, Kallupi M, Sedighim S, Velarde N, Boomhower B, Rizo N, Carrette LLG, George O. Addict Biol. 2023 Sep. PMID: 37644893 DOI
  • A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis. GeneticsGut–Brain Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P. Cell Mol Immunol. 2023 Aug. PMID: 37553429 DOI
  • Microbial short-chain fatty acids regulate drug seeking and transcriptional control in a model of cocaine seeking. StimulantsGut–BrainBehavior Meckel KR, Simpson SS, Godino A, Peck EG, Sens JP, Leonard MZ, George O, Calipari ES, Hofford RS, Kiraly DD. Neuropsychopharmacology. 2023 Aug. PMID: 37528220 DOI
  • Gut Microbiome-Centered Therapies for Alcohol-Associated Liver Disease. AlcoholGut–Brain Ranjbarian T, Schnabl B. Semin Liver Dis. 2023 Aug. PMID: 37527781 DOI
  • Genome-wide association studies of human and rat BMI converge on synapse, epigenome, and hormone signaling networks. Genetics Wright SN, Leger BS, Rosenthal SB, Liu SN, Jia T, Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Garcia Martinez A, George A, Gileta AF, Han W, Netzley AH, King CP, Lamparelli A, Martin C, St Pierre CL, Wang T, Bimschleger H, Richards J, Ishiwari K, Chen H, Flagel SB, Meyer P, Robinson TE, Solberg Woods LC, Kreisberg JF, Ideker T, Palmer AA. Cell Rep. 2023 Jul. PMID: 37527041 DOI
  • Fungal plasma biomarkers in patients admitted for inpatient treatment of alcohol use disorder. AlcoholGut–Brain Fuster D, Llorente C, Garcia-Calvo X, Bolao F, Zuluaga P, Hernández-Rubio A, Casado-Carbajo J, Leis A, Muga R. Alcohol Clin Exp Res (Hoboken). 2023 Jul. PMID: 37364901 DOI
  • Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain. PARC StimulantsBehavior Cheng Y, Dempsey RE, Roodsari SK, Shuboni-Mulligan DD, George O, Sanford LD, Guo ML. Biomedicines. 2023 Jun. PMID: 37509440 DOI
  • Editorial: Opioids and opioid-use disorders. Opioids de Guglielmo G, Kallupi M, Cippitelli A, Caprioli D, Lutfy K. Front Pharmacol. 2023 Jun. PMID: 37397475 DOI
  • Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets. AlcoholGut–Brain Cheng Z, Chen Y, Schnabl B, Chu H, Yang L. J Adv Res. 2023 Jun. PMID: 37356804 DOI
  • Strain and sex-related behavioral variability of oxycodone dependence in rats. PARC OpioidsGeneticsBehavior Doyle MR, Martinez AR, Qiao R, Dirik S, Di Ottavio F, Pascasio G, Martin-Fardon R, Benner C, George O, Telese F, de Guglielmo G. Neuropharmacology. 2023 Jun. PMID: 37327971 DOI
  • Predicting chronic postsurgical pain: current evidence and a novel program to develop predictive biomarker signatures. GeneticsBrain ImagingBehavior Sluka KA, Wager TD, Sutherland SP, Labosky PA, Balach T, Bayman EO, Berardi G, Brummett CM, Burns J, Buvanendran A, Caffo B, Calhoun VD, Clauw D, Chang A, Coffey CS, Dailey DL, Ecklund D, Fiehn O, Fisch KM, Frey Law LA, Harris RE, Harte SE, Howard TD, Jacobs J, Jacobs JM, Jepsen K, Johnston N, Langefeld CD, Laurent LC, Lenzi R, Lindquist MA, Lokshin A, Kahn A, McCarthy RJ, Olivier M, Porter L, Qian WJ, Sankar CA, Satterlee J, Swensen AC, Vance CGT, Waljee J, Wandner LD, Williams DA, Wixson RL, Zhou XJ, A2CPS Consortium. Pain. 2023 Jun. PMID: 37326643 DOI
  • The gut-liver axis and gut microbiota in health and liver disease. AlcoholGut–Brain Hsu CL, Schnabl B. Nat Rev Microbiol. 2023 Jun. PMID: 37316582 DOI
  • Hyperconnectivity of Two Separate Long-Range Cholinergic Systems Contributes to the Reorganization of the Brain Functional Connectivity during Nicotine Withdrawal in Male Mice. NicotineBrain ImagingBehavior Carrette LLG, Kimbrough A, Davoudian PA, Kwan AC, Collazo A, George O. eNeuro. 2023 Jun. PMID: 37295945 DOI
  • Intestinal clock modulates rhythmic hepatic metabolism. Gut–Brain Fondevila MF, Schnabl B. J Hepatol. 2023 Jun. PMID: 37290589 DOI
  • The long non-coding RNA MALAT1 regulates intestine host-microbe interactions and polyposis. GeneticsGut–Brain Long T, Hernandez JE, Ma S, Steele S, Luo C, Li Y, Xie Q, Telese F, Zhou B, Huang WJM. Front Cell Dev Biol. 2023 May. PMID: 37325561 DOI
  • Variant STAT4 and Response to Ruxolitinib in an Autoinflammatory Syndrome. Genetics Baghdassarian H, Blackstone SA, Clay OS, Philips R, Matthiasardottir B, Nehrebecky M, Hua VK, McVicar R, Liu Y, Tucker SM, Randazzo D, Deuitch N, Rosenzweig S, Mark A, Sasik R, Fisch KM, Pimpale Chavan P, Eren E, Watts NR, Ma CA, Gadina M, Schwartz DM, Sanyal A, Werner G, Murdock DR, Horita N, Chowdhury S, Dimmock D, Jepsen K, Remmers EF, Goldbach-Mansky R, Gahl WA, O'Shea JJ, Milner JD, Lewis NE, Chang J, Kastner DL, Torok K, Oda H, Putnam CD, Broderick L. N Engl J Med. 2023 May. PMID: 37256972 DOI
  • Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway. PARC OpioidsStimulantsBehavior Kumaresan V, Lim Y, Juneja P, Tipton AE, de Guglielmo G, Carrette LLG, Kallupi M, Maturin L, Liu Y, George O, Zhang H. Biomedicines. 2023 May. PMID: 37239038 DOI
  • Transcriptional time course after rotator cuff repair in 6 month old female rabbits. Vasquez-Bolanos LS, Gibbons MC, Ruoss S, Wu IT, Esparza MC, Fithian DC, Lane JG, Singh A, Nasamran CA, Fisch KM, Ward SR. Front Physiol. 2023 May. PMID: 37228812 DOI
  • Fecal cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure. AlcoholGut–Brain Hartmann P, Lang S, Schierwagen R, Klein S, Praktiknjo M, Trebicka J, Schnabl B. Hepatobiliary Pancreat Dis Int. 2023 May. PMID: 37198098 DOI
  • Acute alcohol-associated hepatitis: Latest findings in non-invasive biomarkers and treatment. AlcoholGut–Brain Yamazaki T, Schnabl B. Liver Int. 2023 May. PMID: 37183549 DOI
  • CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice. GeneticsBehavior Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. Transl Psychiatry. 2023 May. PMID: 37173343 DOI
  • A novel quantitative trait locus implicates Msh3 in the propensity for genome-wide short tandem repeat expansions in mice. Genetics Maksimov MO, Wu C, Ashbrook DG, Villani F, Colonna V, Mousavi N, Ma N, Lu L, Pritchard JK, Goren A, Williams RW, Palmer AA, Gymrek M. Genome Res. 2023 May. PMID: 37127331 DOI
  • An exponential increase in QTL detection with an increased sample size. PARC Genetics Chitre AS, Polesskaya O, Munro D, Cheng R, Mohammadi P, Holl K, Gao J, Bimschleger H, Martinez AG, George AM, Gileta AF, Han W, Horvath A, Hughson A, Ishiwari K, King CP, Lamparelli A, Versaggi CL, Martin CD, St Pierre CL, Tripi JA, Richards JB, Wang T, Chen H, Flagel SB, Meyer P, Robinson TE, Solberg Woods LC, Palmer AA. Genetics. 2023 May. PMID: 36974931 DOI
  • Reward maximization assessed using a sequential patch depletion task in a large sample of heterogeneous stock rats. PARC GeneticsBehavior Gancarz AM, Mitchell SH, George AM, Martin CD, Turk MC, Bool HM, Aktar F, Kwarteng F, Palmer AA, Meyer PJ, Richards JB, Dietz DM, Ishiwari K. Sci Rep. 2023 Apr. PMID: 37120610 DOI
  • Maladaptive lymphangiogenesis is associated with synovial iron accumulation and delayed clearance in factor VIII-deficient mice after induced hemarthrosis. Cooke EJ, Joseph BC, Nasamran CA, Fisch KM, von Drygalski A. J Thromb Haemost. 2023 Apr. PMID: 37116753 DOI
  • Serum keratin 18-M65 levels detect progressive forms of alcohol-associated liver disease in early noncirrhotic stages. AlcoholGut–BrainBrain Imaging Maccioni L, Horsmans Y, Leclercq I, Schnabl B, Stärkel P. Alcohol Clin Exp Res (Hoboken). 2023 Apr. PMID: 37060262 DOI
  • Toll-like receptor 2 activation in monocytes contributes to systemic inflammation and alcohol-associated liver disease in humans. AlcoholGut–Brain Maccioni L, Kasavuli J, Leclercq S, Pirlot B, Laloux G, Horsmans Y, Leclercq I, Schnabl B, Stärkel P. Hepatol Commun. 2023 Apr. PMID: 37058088 DOI
  • Automated quantitative trait locus analysis (AutoQTL). Genetics Freda PJ, Ghosh A, Zhang E, Luo T, Chitre AS, Polesskaya O, St Pierre CL, Gao J, Martin CD, Chen H, Garcia-Martinez AG, Wang T, Han W, Ishiwari K, Meyer P, Lamparelli A, King CP, Palmer AA, Li R, Moore JH. BioData Min. 2023 Apr. PMID: 37038201 DOI
  • Global and national prevalence of nonalcoholic fatty liver disease in adolescents: An analysis of the global burden of disease study 2019. AlcoholGut–Brain Hartmann P, Zhang X, Loomba R, Schnabl B. Hepatology. 2023 Apr. PMID: 37021791 DOI
  • Focal adhesion is associated with lithium response in bipolar disorder: evidence from a network-based multi-omics analysis. Genetics Niemsiri V, Rosenthal SB, Nievergelt CM, Maihofer AX, Marchetto MC, Santos R, Shekhtman T, Alliey-Rodriguez N, Anand A, Balaraman Y, Berrettini WH, Bertram H, Burdick KE, Calabrese JR, Calkin CV, Conroy C, Coryell WH, DeModena A, Eyler LT, Feeder S, Fisher C, Frazier N, Frye MA, Gao K, Garnham J, Gershon ES, Goes FS, Goto T, Harrington GJ, Jakobsen P, Kamali M, Kelly M, Leckband SG, Lohoff FW, McCarthy MJ, McInnis MG, Craig D, Millett CE, Mondimore F, Morken G, Nurnberger JI, Donovan CO, Øedegaard KJ, Ryan K, Schinagle M, Shilling PD, Slaney C, Stapp EK, Stautland A, Tarwater B, Zandi PP, Alda M, Fisch KM, Gage FH, Kelsoe JR. Mol Psychiatry. 2023 Mar. PMID: 36991131 DOI
  • Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan. GeneticsBehavior Vilar-Ribó L, Cabana-Domínguez J, Martorell L, Ramos-Quiroga JA, Sanchez-Roige S, Palmer AA, Vilella E, Ribasés M, Muntané G, Soler Artigas M. Neuropsychopharmacology. 2023 Mar. PMID: 36906694 DOI
  • Candida albicans-specific Th17 cell-mediated response contributes to alcohol-associated liver disease. AlcoholGut–Brain Zeng S, Rosati E, Saggau C, Messner B, Chu H, Duan Y, Hartmann P, Wang Y, Ma S, Huang WJM, Lee J, Lee SM, Carvalho-Gontijo R, Zhang V, Hoffmann JP, Kolls JK, Raz E, Brenner DA, Kisseleva T, LeibundGut-Landmann S, Bacher P, Stärkel P, Schnabl B. Cell Host Microbe. 2023 Mar. PMID: 36893735 DOI
  • Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells. GeneticsBehavior van der Werf I, Mondala PK, Steel SK, Balaian L, Ladel L, Mason CN, Diep RH, Pham J, Cloos J, Kaspers GJL, Chan WC, Mark A, La Clair JJ, Wentworth P, Fisch KM, Crews LA, Whisenant TC, Burkart MD, Donohoe ME, Jamieson CHM. Cell Rep Med. 2023 Mar. PMID: 36889320 DOI
  • Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice. AlcoholGut–Brain Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. Alcohol Clin Exp Res (Hoboken). 2023 Mar. PMID: 36871955 DOI
  • Sp3 is essential for normal lung morphogenesis and cell cycle progression during mouse embryonic development. McCoy AM, Lakhdari O, Shome S, Caoili K, Hernandez GE, Aghaeepour N, Butcher LD, Fisch K, Prince LS. Development. 2023 Mar. PMID: 36762637 DOI
  • Editorial: Cannabidiol treatment in neurotherapeutic interventions, volume II. Gonzalez-Cuevas G, Navarrete F, Garcia-Gutierrez MS, de Guglielmo G, Manzanares J. Front Pharmacol. 2023 Feb. PMID: 36909164 DOI
  • Safer at school early alert: an observational study of wastewater and surface monitoring to detect COVID-19 in elementary schools. Genetics Fielding-Miller R, Karthikeyan S, Gaines T, Garfein RS, Salido RA, Cantu VJ, Kohn L, Martin NK, Wynn A, Wijaya C, Flores M, Omaleki V, Majnoonian A, Gonzalez-Zuniga P, Nguyen M, Vo AV, Le T, Duong D, Hassani A, Tweeten S, Jepsen K, Henson B, Hakim A, Birmingham A, De Hoff P, Mark AM, Nasamran CA, Rosenthal SB, Moshiri N, Fisch KM, Humphrey G, Farmer S, Tubb HM, Valles T, Morris J, Kang J, Khaleghi B, Young C, Akel AD, Eilert S, Eno J, Curewitz K, Laurent LC, Rosing T, Knight R, SEARCH. Lancet Reg Health Am. 2023 Feb. PMID: 36844610 DOI
  • NIH Toolbox Emotion Battery Findings Among People with HIV: Normative Comparisons and Clinical Associations. Brody LA, Kamalyan L, Karcher K, Guarena LA, Bender AA, McKenna BS, Umlauf A, Franklin D, Marquine MJ, Heaton RK. Patient Relat Outcome Meas. 2023 Feb. PMID: 36814680 DOI
  • IgY antibodies against cytolysin reduce ethanol-induced liver disease in mice. AlcoholGut–Brain Cabré N, Hartmann P, Llorente C, Kouno T, Wang Y, Zeng S, Kim HY, Zhang X, Kisseleva T, Iyer S, Kudumala S, Schnabl B. Hepatology. 2023 Feb. PMID: 36811393 DOI
  • Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease. AlcoholGut–Brain Hsu CL, Wang Y, Duan Y, Chu H, Hartmann P, Llorente C, Zhou R, Schnabl B. Dig Dis Sci. 2023 Feb. PMID: 36807831 DOI
  • Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia. Behavior Zapata RC, Zhang D, Libster A, Porcu A, Montilla-Perez P, Nur A, Xu B, Zhang Z, Correa SM, Liu C, Telese F, Osborn O. Mol Psychiatry. 2023 Feb. PMID: 36765131 DOI
  • Intestinal dendritic cells, gatekeepers preventing ethanol-induced liver disease. AlcoholGut–Brain Llorente C, Rungratanawanich W, Liangpunsakul S. Hepatology. 2023 Jan. PMID: 36930746 DOI
  • Genome-wide association study finds multiple loci associated with intraocular pressure in HS rats. PARC Genetics Fowler S, Wang T, Munro D, Kumar A, Chitre AS, Hollingsworth TJ, Garcia Martinez A, St Pierre CL, Bimschleger H, Gao J, Cheng R, Mohammadi P, Chen H, Palmer AA, Polesskaya O, Jablonski MM. Front Genet. 2023 Jan. PMID: 36793389 DOI
  • Genome-wide association study in a rat model of temperament identifies multiple loci for exploratory locomotion and anxiety-like traits. GeneticsBehavior Chitre AS, Hebda-Bauer EK, Blandino P, Bimschleger H, Nguyen KM, Maras P, Li F, Ozel AB, Pan Y, Polesskaya O, Cheng R, Flagel SB, Watson SJ, Li J, Akil H, Palmer AA. Front Genet. 2023 Jan. PMID: 36712851 DOI
  • Malassezia restricta promotes alcohol-induced liver injury. AlcoholGut–Brain Zeng S, Hartmann P, Park M, Duan Y, Lang S, Llorente C, Wang Y, Cabré N, Fouts DE, Bacher P, Jung WH, Stärkel P, Schnabl B. Hepatol Commun. 2023 Jan. PMID: 36706195 DOI
  • An Ensemble Learning Approach to Improving Prediction of Case Duration for Spine Surgery: Algorithm Development and Validation. Gabriel RA, Harjai B, Simpson S, Du AL, Tully JL, George O, Waterman R. JMIR Perioper Med. 2023 Jan. PMID: 36701181 DOI
  • Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice. AlcoholGut–Brain Hendrikx T, Lang S, Rajcic D, Wang Y, McArdle S, Kim K, Mikulski Z, Schnabl B. Gut. 2023 Jan. PMID: 36690432 DOI
  • Mapping the common gene networks that underlie related diseases. Rosenthal SB, Wright SN, Liu S, Churas C, Chilin-Fuentes D, Chen CH, Fisch KM, Pratt D, Kreisberg JF, Ideker T. Nat Protoc. 2023 Jan. PMID: 36653526 DOI
  • Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome. AlcoholGeneticsGut–Brain Hsu CL, Lang S, Demir M, Fouts DE, Stärkel P, Schnabl B. Hepatology. 2023 Jan. PMID: 36631002 DOI
  • Can a mucosal microbiota signature predict disease severity, survival, and disease recurrence in PSC? Gut–Brain Hartmann P, Schnabl B. Hepatology. 2023 Jan. PMID: 36626635 DOI
  • Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice. Gut–Brain Borin JM, Liu R, Wang Y, Wu TC, Chopyk J, Huang L, Kuo P, Ghose C, Meyer JR, Tu XM, Schnabl B, Pride DT. Gut Microbes. 2023. PMID: 37475473 DOI

2022

  • Fungal infections and the fungal microbiome in hepatobiliary disorders. Gut–Brain Hartmann P, Schnabl B. J Hepatol. 2022 Dec. PMID: 36565724 DOI
  • Hazardous drinking and alcohol use disorders. AlcoholGenetics MacKillop J, Agabio R, Feldstein Ewing SW, Heilig M, Kelly JF, Leggio L, Lingford-Hughes A, Palmer AA, Parry CD, Ray L, Rehm J. Nat Rev Dis Primers. 2022 Dec. PMID: 36550121 DOI
  • Correlation between Serum Steroid Hormones and Gut Microbiota in Patients with Alcohol-Associated Liver Disease. AlcoholGut–Brain Gao B, Zhu Y, Shen W, Stärkel P, Schnabl B. Metabolites. 2022 Nov. PMID: 36422247 DOI
  • Voluntary and forced exposure to ethanol vapor produces similar escalation of alcohol drinking but differential recruitment of brain regions related to stress, habit, and reward in male rats. PARC AlcoholBehavior de Guglielmo G, Simpson S, Kimbrough A, Conlisk D, Baker R, Cantor M, Kallupi M, George O. Neuropharmacology. 2022 Nov. PMID: 36334765 DOI
  • Clinical, environmental, and genetic risk factors for substance use disorders: characterizing combined effects across multiple cohorts. AlcoholNicotineGenetics Barr PB, Driver MN, Kuo SI, Stephenson M, Aliev F, Linnér RK, Marks J, Anokhin AP, Bucholz K, Chan G, Edenberg HJ, Edwards AC, Francis MW, Hancock DB, Harden KP, Kamarajan C, Kaprio J, Kinreich S, Kramer JR, Kuperman S, Latvala A, Meyers JL, Palmer AA, Plawecki MH, Porjesz B, Rose RJ, Schuckit MA, Salvatore JE, Dick DM. Mol Psychiatry. 2022 Nov. PMID: 36195638 DOI
  • Sarcopenia-related gut microbial changes are associated with the risk of complications in people with cirrhosis. Gut–Brain Lee PC, Lee KC, Yang TC, Lu HS, Cheng TY, Chen YJ, Chiou JJ, Huang CW, Yang UC, Chia-Hui Tan E, Chou SH, Kuo YL, Schnabl B, Huang YH, Hou MC. JHEP Rep. 2022 Oct. PMID: 36536957 DOI
  • Chromatin Accessibility and Transcriptional Differences in Human Stem Cell-Derived Early-Stage Retinal Organoids. Jones MK, Agarwal D, Mazo KW, Chopra M, Jurlina SL, Dash N, Xu Q, Ogata AR, Chow M, Hill AD, Kambli NK, Xu G, Sasik R, Birmingham A, Fisch KM, Weinreb RN, Enke RA, Skowronska-Krawczyk D, Wahlin KJ. Cells. 2022 Oct. PMID: 36359808 DOI
  • Modeling placental development and disease using human pluripotent stem cells. Morey R, Bui T, Fisch KM, Horii M. Placenta. 2022 Oct. PMID: 36333266 DOI
  • Inexpensive, Accurate, and Stable Method to Quantitate Blood Alanine Aminotransferase (ALT) Levels. Hartmann P, Schnabl B. Methods Protoc. 2022 Oct. PMID: 36287053 DOI
  • Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model. Rickner HD, Jiang L, Hong R, O'Neill NK, Mojica CA, Snyder BJ, Zhang L, Shaw D, Medalla M, Wolozin B, Cheng CS. Nat Commun. 2022 Oct. PMID: 36271092 DOI
  • The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats. PARC GeneticsBehavior Munro D, Wang T, Chitre AS, Polesskaya O, Ehsan N, Gao J, Gusev A, Woods LCS, Saba LM, Chen H, Palmer AA, Mohammadi P. Nucleic Acids Res. 2022 Oct. PMID: 36263809 DOI
  • Spatial transcriptomics tools allow for regional exploration of heterogeneous muscle pathology in the pre-clinical rabbit model of rotator cuff tear. Ruoss S, Esparza MC, Vasquez-Bolanos LS, Nasamran CA, Fisch KM, Engler AJ, Ward SR. J Orthop Surg Res. 2022 Oct. PMID: 36195913 DOI
  • Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Gut–Brain Knorr J, Kaufmann B, Inzaugarat ME, Holtmann TM, Geisler L, Hundertmark J, Kohlhepp MS, Boosheri LM, Chilin-Fuentes DR, Birmingham A, Fisch KM, Schilling JD, Loosen SH, Trautwein C, Roderburg C, Demir M, Tacke F, Hoffman HM, Feldstein AE, Wree A. Hepatology. 2022 Oct. PMID: 36059147 DOI
  • Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk. AlcoholGenetics Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linnér RK, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM. Transl Psychiatry. 2022 Sep. PMID: 36180423 DOI
  • Liver cirrhosis and immune dysfunction. AlcoholGut–Brain Hasa E, Hartmann P, Schnabl B. Int Immunol. 2022 Sep. PMID: 35792761 DOI
  • Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. AlcoholGut–Brain Carvalho-Gontijo R, Han C, Zhang L, Zhang V, Hosseini M, Mekeel K, Schnabl B, Loomba R, Karin M, Brenner DA, Kisseleva T. Semin Liver Dis. 2022 Aug. PMID: 36001995 DOI
  • Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions. GeneticsBehavior Zuo Y, Iemolo A, Montilla-Perez P, Li HR, Yang X, Telese F. Neuropsychopharmacology. 2022 Aug. PMID: 35995972 DOI
  • Are we compulsively chasing rainbows? PARC Behavior George O, Ahmed SH, Gilpin NW. Neuropsychopharmacology. 2022 Aug. PMID: 35982236 DOI
  • Acetate reprograms gut microbiota during alcohol consumption. AlcoholGeneticsGut–Brain Martino C, Zaramela LS, Gao B, Embree M, Tarasova J, Parker SJ, Wang Y, Chu H, Chen P, Lee KC, Galzerani DD, Gengatharan JM, Lekbua A, Neal M, Knight R, Tsukamoto H, Metallo CM, Schnabl B, Zengler K. Nat Commun. 2022 Aug. PMID: 35941112 DOI
  • Duodenal CD8+ T resident memory cell apoptosis contributes to gut barrier dysfunction and microbial translocation in early alcohol-associated liver disease in humans. AlcoholGut–Brain Maccioni L, Loriot A, Dewulf J, Bommer G, Horsmans Y, Lanthier N, Leclercq I, Schnabl B, Stärkel P. Aliment Pharmacol Ther. 2022 Aug. PMID: 35919965 DOI
  • A Novel Hypomorphic Apex1 Mouse Model Implicates Apurinic/Apyrimidinic Endonuclease 1 in Oxidative DNA Damage Repair in Gastric Epithelial Cells. Genetics Rios-Covian D, Butcher LD, Ablack AL, den Hartog G, Matsubara MT, Ly H, Oates AW, Xu G, Fisch KM, Ahrens ET, Toden S, Brown CC, Kim K, Le D, Eckmann L, Dhar B, Izumi T, Ernst PB, Crowe SE. Antioxid Redox Signal. 2022 Aug. PMID: 35754343 DOI
  • Synovial tissue metabolomic profiling reveal biomarkers of synovial inflammation in patients with osteoarthritis. Murillo-Saich JD, Coras R, Meyer R, Llorente C, Lane NE, Guma M. Osteoarthr Cartil Open. 2022 Jul. PMID: 36474936 DOI
  • Effects of single and dual hypocretin-receptor blockade or knockdown of hypocretin projections to the central amygdala on alcohol drinking in dependent male rats. PARC AlcoholBehavior Aldridge GM, Zarin TA, Brandner AJ, George O, Gilpin NW, Repunte-Canonigo V, Sanna PP, Koob GF, Vendruscolo LF, Schmeichel BE. Addict Neurosci. 2022 Jul. PMID: 35965958 DOI
  • Reelin deficiency exacerbates cocaine-induced hyperlocomotion by enhancing neuronal activity in the dorsomedial striatum. StimulantsGeneticsBehavior de Guglielmo G, Iemolo A, Nur A, Turner A, Montilla-Perez P, Martinez A, Crook C, Roberts A, Telese F. Genes Brain Behav. 2022 Jul. PMID: 35906757 DOI
  • Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Genetics Karthikeyan S, Levy JI, De Hoff P, Humphrey G, Birmingham A, Jepsen K, Farmer S, Tubb HM, Valles T, Tribelhorn CE, Tsai R, Aigner S, Sathe S, Moshiri N, Henson B, Mark AM, Hakim A, Baer NA, Barber T, Belda-Ferre P, Chacón M, Cheung W, Cresini ES, Eisner ER, Lastrella AL, Lawrence ES, Marotz CA, Ngo TT, Ostrander T, Plascencia A, Salido RA, Seaver P, Smoot EW, McDonald D, Neuhard RM, Scioscia AL, Satterlund AM, Simmons EH, Abelman DB, Brenner D, Bruner JC, Buckley A, Ellison M, Gattas J, Gonias SL, Hale M, Hawkins F, Ikeda L, Jhaveri H, Johnson T, Kellen V, Kremer B, Matthews G, McLawhon RW, Ouillet P, Park D, Pradenas A, Reed S, Riggs L, Sanders A, Sollenberger B, Song A, White B, Winbush T, Aceves CM, Anderson C, Gangavarapu K, Hufbauer E, Kurzban E, Lee J, Matteson NL, Parker E, Perkins SA, Ramesh KS, Robles-Sikisaka R, Schwab MA, Spencer E, Wohl S, Nicholson L, McHardy IH, Dimmock DP, Hobbs CA, Bakhtar O, Harding A, Mendoza A, Bolze A, Becker D, Cirulli ET, Isaksson M, Schiabor Barrett KM, Washington NL, Malone JD, Schafer AM, Gurfield N, Stous S, Fielding-Miller R, Garfein RS, Gaines T, Anderson C, Martin NK, Schooley R, Austin B, MacCannell DR, Kingsmore SF, Lee W, Shah S, McDonald E, Yu AT, Zeller M, Fisch KM, Longhurst C, Maysent P, Pride D, Khosla PK, Laurent LC, Yeo GW, Andersen KG, Knight R. Nature. 2022 Jul. PMID: 35798029 DOI
  • Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities. Genetics Mallard TT, Linnér RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okbay A, de Vlaming R, Meddens SFW, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Palmer AA, Davis LK, Tucker-Drob EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Cell Genom. 2022 Jun. PMID: 35812988 DOI
  • Cross-ancestry genomic research: time to close the gap. Genetics Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. Neuropsychopharmacology. 2022 Jun. PMID: 35739257 DOI
  • Promises of microbiome-based therapies. Gut–Brain Bajaj JS, Ng SC, Schnabl B. J Hepatol. 2022 Jun. PMID: 35589257 DOI
  • Nonalcoholic fatty liver disease risk and histologic severity are associated with genetic polymorphisms in children. AlcoholGeneticsGut–Brain Goyal NP, Rosenthal SB, Nasamran C, Behling CA, Angeles JE, Fishbein MH, Harlow KE, Jain AK, Molleston JP, Newton KP, Ugalde-Nicalo P, Xanthankos SA, Yates K, Schork NJ, Fisch KM, Schwimmer JB, NASH Clinical Research Network. Hepatology. 2022 Jun. PMID: 35560106 DOI
  • Accelerating Opioid Use Disorders Research by Integrating Multiple Data Modalities. Opioids Bianchi SB, Jeffery AD, Samuels DC, Schirle L, Palmer AA, Sanchez-Roige S. Complex Psychiatry. 2022 May. PMID: 36545043 DOI
  • Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. PARC OpioidsStimulantsBehavior Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. Front Neurosci. 2022 May. PMID: 35651629 DOI
  • Genetic characterization of outbred Sprague Dawley rats and utility for genome-wide association studies. GeneticsBehavior Gileta AF, Fitzpatrick CJ, Chitre AS, St Pierre CL, Joyce EV, Maguire RJ, McLeod AM, Gonzales NM, Williams AE, Morrow JD, Robinson TE, Flagel SB, Palmer AA. PLoS Genet. 2022 May. PMID: 35639796 DOI
  • Lipidomics for the Prediction of Progressive Liver Disease in Patients with Alcohol Use Disorder. AlcoholGut–Brain Gao B, Zeng S, Maccioni L, Shi X, Armando A, Quehenberger O, Zhang X, Stärkel P, Schnabl B. Metabolites. 2022 May. PMID: 35629937 DOI
  • Selective PPARδ agonist seladelpar suppresses bile acid synthesis by reducing hepatocyte CYP7A1 via the fibroblast growth factor 21 signaling pathway. Gut–Brain Kouno T, Liu X, Zhao H, Kisseleva T, Cable EE, Schnabl B. J Biol Chem. 2022 May. PMID: 35605662 DOI
  • Derivation of functional trophoblast stem cells from primed human pluripotent stem cells. Soncin F, Morey R, Bui T, Requena DF, Cheung VC, Kallol S, Kittle R, Jackson MG, Farah O, Chousal J, Meads M, Pizzo D, Horii M, Fisch KM, Parast MM. Stem Cell Reports. 2022 May. PMID: 35594858 DOI
  • A natural mutator allele shapes mutation spectrum variation in mice. Genetics Sasani TA, Ashbrook DG, Beichman AC, Lu L, Palmer AA, Williams RW, Pritchard JK, Harris K. Nature. 2022 May. PMID: 35545679 DOI
  • Multi-Site Observational Study to Assess Biomarkers for Susceptibility or Resilience to Chronic Pain: The Acute to Chronic Pain Signatures (A2CPS) Study Protocol. Brain Imaging Berardi G, Frey-Law L, Sluka KA, Bayman EO, Coffey CS, Ecklund D, Vance CGT, Dailey DL, Burns J, Buvanendran A, McCarthy RJ, Jacobs J, Zhou XJ, Wixson R, Balach T, Brummett CM, Clauw D, Colquhoun D, Harte SE, Harris RE, Williams DA, Chang AC, Waljee J, Fisch KM, Jepsen K, Laurent LC, Olivier M, Langefeld CD, Howard TD, Fiehn O, Jacobs JM, Dakup P, Qian WJ, Swensen AC, Lokshin A, Lindquist M, Caffo BS, Crainiceanu C, Zeger S, Kahn A, Wager T, Taub M, Ford J, Sutherland SP, Wandner LD. Front Med (Lausanne). 2022 Apr. PMID: 35547202 DOI
  • Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. AlcoholGeneticsBehavior Parker CC, Philip VM, Gatti DM, Kasparek S, Kreuzman AM, Kuffler L, Mansky B, Masneuf S, Sharif K, Sluys E, Taterra D, Taylor WM, Thomas M, Polesskaya O, Palmer AA, Holmes A, Chesler EJ. Alcohol Clin Exp Res. 2022 Apr. PMID: 35383961 DOI
  • The Host-Microbiome Response to Hyperbaric Oxygen Therapy in Ulcerative Colitis Patients. GeneticsGut–Brain Gonzalez CG, Mills RH, Kordahi MC, Carrillo-Terrazas M, Secaira-Morocho H, Widjaja CE, Tsai MS, Mittal Y, Yee BA, Vargas F, Weldon K, Gauglitz JM, Delaroque C, Sauceda C, Rossitto LA, Ackermann G, Humphrey G, Swafford AD, Siegel CA, Buckey JC, Raffals LE, Sadler C, Lindholm P, Fisch KM, Valaseck M, Suriawinata A, Yeo GW, Ghosh P, Chang JT, Chu H, Dorrestein P, Zhu Q, Chassaing B, Knight R, Gonzalez DJ, Dulai PS. Cell Mol Gastroenterol Hepatol. 2022 Apr. PMID: 35378331 DOI
  • Intestinal virome in patients with alcohol use disorder and after abstinence. AlcoholGeneticsGut–Brain Hsu CL, Zhang X, Jiang L, Lang S, Hartmann P, Pride D, Fouts DE, Stärkel P, Schnabl B. Hepatol Commun. 2022 Apr. PMID: 35368152 DOI
  • SNPs, short tandem repeats, and structural variants are responsible for differential gene expression across C57BL/6 and C57BL/10 substrains. Genetics Mortazavi M, Ren Y, Saini S, Antaki D, St Pierre CL, Williams A, Sohni A, Wilkinson MF, Gymrek M, Sebat J, Palmer AA. Cell Genom. 2022 Mar. PMID: 35720252 DOI
  • Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats. PARC OpioidsBehavior Fu Y, Lorrai I, Zorman B, Mercatelli D, Shankula C, Marquez Gaytan J, Lefebvre C, de Guglielmo G, Kim HR, Sumazin P, Giorgi FM, Repunte-Canonigo V, Sanna PP. Viruses. 2022 Mar. PMID: 35458399 DOI
  • The Lung Microenvironment Instructs Gene Transcription in Neonatal and Adult Alveolar Macrophages. Honda A, Hoeksema MA, Sakai M, Lund SJ, Lakhdari O, Butcher LD, Rambaldo TC, Sekiya NM, Nasamran CA, Fisch KM, Sajti E, Glass CK, Prince LS. J Immunol. 2022 Mar. PMID: 35354612 DOI
  • The ViReflow pipeline enables user friendly large scale viral consensus genome reconstruction. Moshiri N, Fisch KM, Birmingham A, DeHoff P, Yeo GW, Jepsen K, Laurent LC, Knight R. Sci Rep. 2022 Mar. PMID: 35332213 DOI
  • Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. PARC StimulantsGeneticsBehavior Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. Front Behav Neurosci. 2022 Mar. PMID: 35316955 DOI
  • RORγt phosphorylation protects against T cell-mediated inflammation. Ma S, Patel SA, Abe Y, Chen N, Patel PR, Cho BS, Abbasi N, Zeng S, Schnabl B, Chang JT, Huang WJM. Cell Rep. 2022 Mar. PMID: 35294872 DOI
  • Behavioral effects of ethanol in the Red Swamp Crayfish (Procambarus clarkii). AlcoholBehavior Gutierrez A, Creehan KM, de Guglielmo G, Roberts AJ, Taffe MA. J Exp Anal Behav. 2022 Mar. PMID: 35261037 DOI
  • A mutant allele of glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting. GeneticsBehavior Sanchez-Roige S, Barnes SA, Mallari J, Wood R, Polesskaya O, Palmer AA. Genes Brain Behav. 2022 Mar. PMID: 35243767 DOI
  • Effect of rifaximin on infections, acute-on-chronic liver failure and mortality in alcoholic hepatitis: A pilot study (RIFA-AH). AlcoholGut–Brain Jiménez C, Ventura-Cots M, Sala M, Calafat M, Garcia-Retortillo M, Cirera I, Cañete N, Soriano G, Poca M, Simón-Talero M, Altamirano J, Lucey M, Garcia-Tsao G, Brown RS, Schwabe RF, Verna EC, Schnabl B, Bosques-Padilla F, Mathurin P, Caballería J, Louvet A, Shawcross DL, Abraldes JG, Genescà J, Bataller R, Vargas V. Liver Int. 2022 Mar. PMID: 35220659 DOI
  • Linking drug and food addiction via compulsive appetite. PARC AlcoholStimulantsBehavior Laque A, Wagner GE, Matzeu A, De Ness GL, Kerr TM, Carroll AM, de Guglielmo G, Nedelescu H, Buczynski MW, Gregus AM, Jhou TC, Zorrilla EP, Martin-Fardon R, Koya E, Ritter RC, Weiss F, Suto N. Br J Pharmacol. 2022 Mar. PMID: 35023154 DOI
  • Systemic Activin Is Elevated in Patients With Severe Alcoholic Hepatitis. Alcohol Staudacher JJ, Bauer J, Atkinson SR, Thursz M, Lang S, Schnabl B, Wiley MB, Carr R, Jung B. Gastro Hep Adv. 2022 Feb. PMID: 35602917 DOI
  • Immune Response of an Oral Enterococcus faecalis Phage Cocktail in a Mouse Model of Ethanol-Induced Liver Disease. AlcoholGut–Brain Mendes BG, Duan Y, Schnabl B. Viruses. 2022 Feb. PMID: 35336897 DOI
  • Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders. PARC GeneticsBehavior Gunturkun MH, Wang T, Chitre AS, Garcia Martinez A, Holl K, St Pierre C, Bimschleger H, Gao J, Cheng R, Polesskaya O, Solberg Woods LC, Palmer AA, Chen H. Front Psychiatry. 2022 Feb. PMID: 35237186 DOI
  • Development of a Robotic Shear Wave Elastography System for Noninvasive Staging of Liver Disease in Murine Models. AlcoholGut–BrainBrain Imaging Czernuszewicz TJ, Aji AM, Moore CJ, Montgomery SA, Velasco B, Torres G, Anand KS, Johnson KA, Deal AM, Zukić D, McCormick M, Schnabl B, Gallippi CM, Dayton PA, Gessner RC. Hepatol Commun. 2022 Feb. PMID: 35202510 DOI
  • Microstructural meal pattern analysis reveals a paradoxical acute increase in food intake after nicotine despite its long-term anorexigenic effects. PARC AlcoholNicotineBehavior Shankar K, Ambroggi F, George O. Psychopharmacology (Berl). 2022 Feb. PMID: 35129671 DOI
  • Machine learning approach to predicting persistent opioid use following lower extremity joint arthroplasty. Opioids Gabriel RA, Harjai B, Prasad RS, Simpson S, Chu I, Fisch KM, Said ET. Reg Anesth Pain Med. 2022 Feb. PMID: 35115414 DOI
  • Role of the Gut Microbiota in Parenteral Nutrition-Associated Liver Disease: From Current Knowledge to Future Opportunities. Gut–Brain Jiang L, Wang Y, Xiao Y, Wang Y, Yan J, Schnabl B, Cai W. J Nutr. 2022 Feb. PMID: 34734271 DOI
  • Gut Microbiome and Alcohol-associated Liver Disease. AlcoholGut–Brain Philips CA, Schnabl B, Bajaj JS. J Clin Exp Hepatol. 2022 Jan. PMID: 36157139 DOI
  • Colesevelam ameliorates non-alcoholic steatohepatitis and obesity in mice. AlcoholGut–Brain Hartmann P, Duan Y, Miyamoto Y, Demir M, Lang S, Hasa E, Stern P, Yamashita D, Conrad M, Eckmann L, Schnabl B. Hepatol Int. 2022 Jan. PMID: 35075592 DOI
  • Low versus high level of response to alcohol affects amygdala functional connectivity during processing of emotional stimuli. AlcoholBrain Imaging McKenna BS, Anthenelli RM, Smith TL, Schuckit MA. Alcohol Clin Exp Res. 2022 Jan. PMID: 35064942 DOI
  • Liver specific, systemic and genetic contributors to alcohol-related liver disease progression. AlcoholGeneticsGut–Brain Schnabl B, Arteel GE, Stickel F, Hengstler J, Vartak N, Ghallab A, Dooley S, Li Y, Schwabe RF. Z Gastroenterol. 2022 Jan. PMID: 35042252 DOI
  • Polygenic transcriptome risk scores (PTRS) can improve portability of polygenic risk scores across ancestries. PARC Genetics Liang Y, Pividori M, Manichaikul A, Palmer AA, Cox NJ, Wheeler HE, Im HK. Genome Biol. 2022 Jan. PMID: 35027082 DOI
  • Roles for the mycobiome in liver disease. Gut–Brain Zeng S, Schnabl B. Liver Int. 2022 Jan. PMID: 34995410 DOI
  • Clinical, histological and molecular profiling of different stages of alcohol-related liver disease. AlcoholGut–Brain Ventura-Cots M, Argemi J, Jones PD, Lackner C, El Hag M, Abraldes JG, Alvarado E, Clemente A, Ravi S, Alves A, Alboraie M, Altamirano J, Barace S, Bosques F, Brown R, Caballeria J, Cabezas J, Carvalhana S, Cortez-Pinto H, Costa A, Degré D, Fernandez-Carrillo C, Ganne-Carrie N, Garcia-Tsao G, Genesca J, Koskinas J, Lanthier N, Louvet A, Lozano JJ, Lucey MR, Masson S, Mathurin P, Mendez-Sanchez N, Miquel R, Moreno C, Mounajjed T, Odena G, Kim W, Sancho-Bru P, Warren Sands R, Szafranska J, Verset L, Schnabl B, Sempoux C, Shah V, Shawcross DL, Stauber RE, Straub BK, Verna E, Tiniakos D, Trépo E, Vargas V, Villanueva C, Woosley JT, Ziol M, Mueller S, Stärkel P, Bataller R. Gut. 2022 Jan. PMID: 34992134 DOI
  • Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. NicotineBehavior Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. Eur J Neurosci. 2022 Jan. PMID: 34963197 DOI
  • Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility. GeneticsBehavior Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J. G3 (Bethesda). 2022 Jan. PMID: 34791208 DOI
  • Mutant Huntingtin Protein Interaction Map Implicates Dysregulation of Multiple Cellular Pathways in Neurodegeneration of Huntington's Disease. Genetics Podvin S, Rosenthal SB, Poon W, Wei E, Fisch KM, Hook V. J Huntingtons Dis. 2022. PMID: 35871359 DOI

2021

  • The fecal mycobiome in non-alcoholic fatty liver disease. AlcoholGut–Brain Demir M, Lang S, Hartmann P, Duan Y, Martin A, Miyamoto Y, Bondareva M, Zhang X, Wang Y, Kasper P, Bang C, Roderburg C, Tacke F, Steffen HM, Goeser T, Kruglov A, Eckmann L, Stärkel P, Fouts DE, Schnabl B. J Hepatol. 2021 Dec. PMID: 34896404 DOI
  • CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. AlcoholGut–Brain Duan Y, Chu H, Brandl K, Jiang L, Zeng S, Meshgin N, Papachristoforou E, Argemi J, Mendes BG, Wang Y, Su H, Sun W, Llorente C, Hendrikx T, Liu X, Hosseini M, Kisseleva T, Brenner DA, Bataller R, Ramachandran P, Karin M, Fu W, Schnabl B. Nat Commun. 2021 Dec. PMID: 34887405 DOI
  • RNA binding protein DDX5 directs tuft cell specification and function to regulate microbial repertoire and disease susceptibility in the intestine. Gut–Brain Long T, Abbasi N, Hernandez JE, Li Y, Sayed IM, Ma S, Iemolo A, Yee BA, Yeo GW, Telese F, Ghosh P, Das S, Huang WJM. Gut. 2021 Dec. PMID: 34853057 DOI
  • Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use. AlcoholNicotineGeneticsBehavior Huggett SB, Johnson EC, Hatoum AS, Lai D, Srijeyanthan J, Bubier JA, Chesler EJ, Agrawal A, Palmer AA, Edenberg HJ, Palmer RHC. Alcohol Clin Exp Res. 2021 Dec. PMID: 34751961 DOI
  • Host Factors in Dysregulation of the Gut Barrier Function during Alcohol-Associated Liver Disease. AlcoholGut–Brain Maccioni L, Leclercq IA, Schnabl B, Stärkel P. Int J Mol Sci. 2021 Nov. PMID: 34884492 DOI
  • FACTORS CONTRIBUTING TO THE ESCALATION OF ALCOHOL CONSUMPTION. Alcohol Bowen MT, George O, Muskiewicz DE, Hall FS. Neurosci Biobehav Rev. 2021 Nov. PMID: 34839930 DOI
  • Integrative Analysis of Metabolome and Microbiome in Patients with Progressive Alcohol-Associated Liver Disease. AlcoholGut–Brain Gao B, Zhu Y, Gao N, Shen W, Stärkel P, Schnabl B. Metabolites. 2021 Nov. PMID: 34822424 DOI
  • Bacteriophages and their potential for treatment of gastrointestinal diseases. Gut–Brain Duan Y, Young R, Schnabl B. Nat Rev Gastroenterol Hepatol. 2021 Nov. PMID: 34782783 DOI
  • Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats. PARC StimulantsBehavior Kallupi M, Kononoff J, Melas PA, Qvist JS, de Guglielmo G, Kandel ER, George O. Brain Stimul. 2021 Nov. PMID: 34742997 DOI
  • Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry. AlcoholOpioidsGeneticsBehavior Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum AS, Sealock J, Davis LK, Elson SL, 23andMe Research Team, Palmer AA. Mol Psychiatry. 2021 Nov. PMID: 34728798 DOI
  • FOXR1 regulates stress response pathways and is necessary for proper brain development. Mota A, Waxman HK, Hong R, Lagani GD, Niu SY, Bertherat FL, Wolfe L, Malicdan CM, Markello TC, Adams DR, Gahl WA, Cheng CS, Beffert U, Ho A. PLoS Genet. 2021 Nov. PMID: 34723967 DOI
  • Characterization of the Brain Functional Architecture of Psychostimulant Withdrawal Using Single-Cell Whole-Brain Imaging. StimulantsNicotineBrain ImagingBehavior Kimbrough A, Kallupi M, Smith LC, Simpson S, Collazo A, George O. eNeuro. 2021 Nov. PMID: 34580158 DOI
  • Editorial: Cannabidiol Treatment in Neurotherapeutic Interventions. Gonzalez-Cuevas G, Garcia-Gutierrez MS, Navarrete F, de Guglielmo G, Manzanares J. Front Pharmacol. 2021 Oct. PMID: 34733162 DOI
  • Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders. PARC AlcoholGut–BrainBehavior Simpson S, Mclellan R, Wellmeyer E, Matalon F, George O. J Neuroimmune Pharmacol. 2021 Oct. PMID: 34694571 DOI
  • Nigrostriatal dopamine signals sequence-specific action-outcome prediction errors. GeneticsGut–BrainBehavior Hollon NG, Williams EW, Howard CD, Li H, Traut TI, Jin X. Curr Biol. 2021 Oct. PMID: 34637751 DOI
  • Optogenetic stimulation of striatal patches modifies habit formation and inhibits dopamine release. GeneticsBehavior Nadel JA, Pawelko SS, Scott JR, McLaughlin R, Fox M, Ghanem M, van der Merwe R, Hollon NG, Ramsson ES, Howard CD. Sci Rep. 2021 Oct. PMID: 34615966 DOI
  • Corrigendum: Multicenter Analysis of Liver Injury Patterns and Mortality in COVID-19. Gut–Brain Chu H, Bai T, Chen L, Hu L, Xiao L, Yao L, Zhu R, Niu X, Li Z, Zhang L, Han C, Song S, He Q, Zhao Y, Zhu Q, Chen H, Schnabl B, Yang L, Hou X. Front Med (Lausanne). 2021 Sep. PMID: 34604269 DOI
  • How nicotine withdrawal symptoms fight each other: interpeduncular GABA neuron activity dynamically controls negative affect vs. coping behavior. NicotineBehavior Avelar AJ, George O. Neuropsychopharmacology. 2021 Sep. PMID: 34593977 DOI
  • Extrachromosomal DNA in HPV-Mediated Oropharyngeal Cancer Drives Diverse Oncogene Transcription. Genetics Pang J, Nguyen N, Luebeck J, Ball L, Finegersh A, Ren S, Nakagawa T, Flagg M, Sadat S, Mischel PS, Xu G, Fisch K, Guo T, Cahill G, Panuganti B, Bafna V, Califano J. Clin Cancer Res. 2021 Sep. PMID: 34548317 DOI
  • Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce. Keehner J, Horton LE, Binkin NJ, Laurent LC, SEARCH Alliance, Pride D, Longhurst CA, Abeles SR, Torriani FJ. N Engl J Med. 2021 Sep. PMID: 34469645 DOI
  • Update on the Role of the Gut Microbiota on Alcohol-Associated Liver Disease. AlcoholGut–Brain Schnabl B. Gastroenterol Hepatol (N Y). 2021 Aug. PMID: 34602901
  • Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease. AlcoholGeneticsGut–Brain Qian M, Liu J, Zhao D, Cai P, Pan C, Jia W, Gao Y, Zhang Y, Zhang N, Zhang Y, Zhang Q, Wu D, Shan C, Zhang M, Schnabl B, Yang S, Shen X, Wang L. Cell Mol Gastroenterol Hepatol. 2021 Aug. PMID: 34454169 DOI
  • Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction. OpioidsGeneticsBehavior Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD, Dick DM. Nat Neurosci. 2021 Aug. PMID: 34446935 DOI
  • Intestinal virome and therapeutic potential of bacteriophages in liver disease. Gut–Brain Hsu CL, Duan Y, Fouts DE, Schnabl B. J Hepatol. 2021 Aug. PMID: 34437908 DOI
  • Transcriptional Time Course After Rotator Cuff Tear. Behavior Vasquez-Bolanos LS, Gibbons MC, Ruoss S, Wu IT, Vargas-Vila M, Hyman SA, Esparza MC, Fithian DC, Lane JG, Singh A, Nasamran CA, Fisch KM, Ward SR. Front Physiol. 2021 Aug. PMID: 34421646 DOI
  • Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. PARC StimulantsGeneticsBehavior Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. Psychopharmacology (Berl). 2021 Aug. PMID: 34415376 DOI
  • A convergent molecular network underlying autism and congenital heart disease. Genetics Rosenthal SB, Willsey HR, Xu Y, Mei Y, Dea J, Wang S, Curtis C, Sempou E, Khokha MK, Chi NC, Willsey AJ, Fisch KM, Ideker T. Cell Syst. 2021 Aug. PMID: 34411509 DOI
  • Psychiatric Comorbidity and Multimorbidity in the EAGLES Trial: Descriptive Correlates and Associations With Neuropsychiatric Adverse Events, Treatment Adherence, and Smoking Cessation. Nicotine Correa JB, Lawrence D, McKenna BS, Gaznick N, Saccone PA, Dubrava S, Doran N, Anthenelli RM. Nicotine Tob Res. 2021 Aug. PMID: 33788933 DOI
  • Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder. AlcoholGut–Brain Hartmann P, Lang S, Zeng S, Duan Y, Zhang X, Wang Y, Bondareva M, Kruglov A, Fouts DE, Stärkel P, Schnabl B. Front Physiol. 2021 Jul. PMID: 34349667 DOI
  • Dissecting indirect genetic effects from peers in laboratory mice. GeneticsBehavior Baud A, Casale FP, Barkley-Levenson AM, Farhadi N, Montillot C, Yalcin B, Nicod J, Palmer AA, Stegle O. Genome Biol. 2021 Jul. PMID: 34311762 DOI
  • Transient genomic instability drives tumorigenesis through accelerated clonal evolution. Genetics Shoshani O, Bakker B, de Haan L, Tijhuis AE, Wang Y, Kim DH, Maldonado M, Demarest MA, Artates J, Zhengyu O, Mark A, Wardenaar R, Sasik R, Spierings DCJ, Vitre B, Fisch K, Foijer F, Cleveland DW. Genes Dev. 2021 Jul. PMID: 34266887 DOI
  • Functional validation of a finding from a mouse genome-wide association study shows that Azi2 influences the acute locomotor stimulant response to methamphetamine. StimulantsGenetics Zhou X, Barkley-Levenson AM, Montilla-Perez P, Telese F, Palmer AA. Genes Brain Behav. 2021 Jul. PMID: 34173327 DOI
  • The Level of Alcohol Consumption in the Prior Year Does Not Impact Clinical Outcomes in Patients With Alcohol-Associated Hepatitis. AlcoholGut–Brain Musto JA, Eickhoff J, Ventura-Cots M, Abraldes JG, Bosques-Padilla F, Verna EC, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross D, Louvet A, Mathurin P, Garcia-Tsao G, Schnabl B, Bataller R, Lucey MR. Liver Transpl. 2021 Jul. PMID: 34109723 DOI
  • Relationship between level of response to alcohol and acute tolerance. Alcohol Anthenelli RM, McKenna BS, Smith TL, Schuckit MA. Alcohol Clin Exp Res. 2021 Jul. PMID: 34086362 DOI
  • Selective Inhibition of Phosphodiesterase 7 Enzymes Reduces Motivation for Nicotine Use through Modulation of Mesolimbic Dopaminergic Transmission. PARC NicotineBehavior Ciccocioppo R, de Guglielmo G, Li HW, Melis M, Caffino L, Shen Q, Domi A, Fumagalli F, Demopulos GA, Gaitanaris GA. J Neurosci. 2021 Jul. PMID: 34083258 DOI
  • The microbiota in cirrhosis and its role in hepatic decompensation. AlcoholGut–Brain Trebicka J, Macnaughtan J, Schnabl B, Shawcross DL, Bajaj JS. J Hepatol. 2021 Jul. PMID: 34039493 DOI
  • Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice. AlcoholGut–Brain Cabré N, Duan Y, Llorente C, Conrad M, Stern P, Yamashita D, Schnabl B. Cells. 2021 Jun. PMID: 34198609 DOI
  • Mapping Pathways by Which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay Between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use. AlcoholGeneticsBehavior Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JR, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA, Externalizing Consortium, Dick DM. Behav Genet. 2021 Jun. PMID: 34117972 DOI
  • (Pro)renin Receptor Knockdown Attenuates Liver Fibrosis Through Inactivation of ERK/TGF-β1/SMAD3 Pathway. Gut–Brain Hsieh YC, Lee KC, Lei HJ, Lan KH, Huo TI, Lin YT, Chan CC, Schnabl B, Huang YH, Hou MC, Lin HC. Cell Mol Gastroenterol Hepatol. 2021 Jun. PMID: 34087453 DOI
  • A semiparametric model for between-subject attributes: Applications to beta-diversity of microbiome data. Gut–Brain Liu J, Zhang X, Chen T, Wu T, Lin T, Jiang L, Lang S, Liu L, Natarajan L, Tu JX, Kosciolek T, Morton J, Nguyen TT, Schnabl B, Knight R, Feng C, Zhong Y, Tu XM. Biometrics. 2021 Jun. PMID: 34010477 DOI
  • The Cocaine and Oxycodone Biobanks, Two Repositories from Genetically Diverse and Behaviorally Characterized Rats for the Study of Addiction. PARC OpioidsStimulantsGeneticsGut–BrainBehavior Carrette LLG, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Martinez AR, Kononoff J, Kimbrough A, Simpson S, Smith LC, Shankar K, Ramirez FJ, Chitre AS, Lin B, Polesskaya O, Solberg Woods LC, Palmer AA, George O. eNeuro. 2021 Jun. PMID: 33875455 DOI
  • Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. AlcoholGut–Brain Ganguly S, Muench GA, Shang L, Rosenthal SB, Rahman G, Wang R, Wang Y, Kwon HC, Diomino AM, Kisseleva T, Soorosh P, Hosseini M, Knight R, Schnabl B, Brenner DA, Dhar D. Cell Mol Gastroenterol Hepatol. 2021 May. PMID: 34062281 DOI
  • Extremes of age are associated with differences in the expression of selected pattern recognition receptor genes and ACE2, the receptor for SARS-CoV-2: implications for the epidemiology of COVID-19 disease. Genetics Bickler SW, Cauvi DM, Fisch KM, Prieto JM, Sykes AG, Thangarajah H, Lazar DA, Ignacio RC, Gerstmann DR, Ryan AF, Bickler PE, De Maio A. BMC Med Genomics. 2021 May. PMID: 34030677 DOI
  • Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts. AlcoholGenetics Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edenberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke TK, Palmer AA, Sanchez-Roige S. Am J Psychiatry. 2021 May. PMID: 33985350 DOI
  • Combined analysis of gut microbiota, diet and PNPLA3 polymorphism in biopsy-proven non-alcoholic fatty liver disease. AlcoholGeneticsGut–Brain Lang S, Martin A, Zhang X, Farowski F, Wisplinghoff H, J G T Vehreschild M, Krawczyk M, Nowag A, Kretzschmar A, Scholz C, Kasper P, Roderburg C, Mohr R, Lammert F, Tacke F, Schnabl B, Goeser T, Steffen HM, Demir M. Liver Int. 2021 May. PMID: 33896117 DOI
  • The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Brain Imaging Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. Front Syst Neurosci. 2021 Apr. PMID: 33967705 DOI
  • An Introduction to Next Generation Sequencing Bioinformatic Analysis in Gut Microbiome Studies. GeneticsGut–Brain Gao B, Chi L, Zhu Y, Shi X, Tu P, Li B, Yin J, Gao N, Shen W, Schnabl B. Biomolecules. 2021 Apr. PMID: 33918473 DOI
  • Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats. AlcoholStimulantsNicotineBehavior Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. Psychopharmacology (Berl). 2021 Apr. PMID: 33909102 DOI
  • Integration of evidence across human and model organism studies: A meeting report. GeneticsBehavior Palmer RHC, Johnson EC, Won H, Polimanti R, Kapoor M, Chitre A, Bogue MA, Benca-Bachman CE, Parker CC, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach BC, Gaddis NC, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Lu Q, Shen L, Philip V, Gelernter J, Bierut LJ, Hancock DB, Edenberg HJ, Johnson EO, Nestler EJ, Barr PB, Prins P, Smith DJ, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobson D, Palmer AA, Miles M, Chesler EJ, Emerson J, Agrawal A, Martone M, Williams RW. Genes Brain Behav. 2021 Apr. PMID: 33893716 DOI
  • NASA GeneLab RNA-seq consensus pipeline: standardized processing of short-read RNA-seq data. Overbey EG, Saravia-Butler AM, Zhang Z, Rathi KS, Fogle H, da Silveira WA, Barker RJ, Bass JJ, Beheshti A, Berrios DC, Blaber EA, Cekanaviciute E, Costa HA, Davin LB, Fisch KM, Gebre SG, Geniza M, Gilbert R, Gilroy S, Hardiman G, Herranz R, Kidane YH, Kruse CPS, Lee MD, Liefeld T, Lewis NG, McDonald JT, Meller R, Mishra T, Perera IY, Ray S, Reinsch SS, Rosenthal SB, Strong M, Szewczyk NJ, Tahimic CGT, Taylor DM, Vandenbrink JP, Villacampa A, Weging S, Wolverton C, Wyatt SE, Zea L, Costes SV, Galazka JM. iScience. 2021 Mar. PMID: 33870146 DOI
  • Strategies to Identify Mesenchymal Stromal Cells in Minimally Manipulated Human Bone Marrow Aspirate Concentrate Lack Consensus. Ruoss S, Walker JT, Nasamran CA, Fisch KM, Paez CJ, Parekh JN, Ball ST, Chen JL, Ahmed SS, Ward SR. Am J Sports Med. 2021 Mar. PMID: 33646886 DOI
  • Fungi-Bacteria Correlation in Alcoholic Hepatitis Patients. AlcoholGeneticsGut–Brain Gao B, Zhang X, Schnabl B. Toxins (Basel). 2021 Feb. PMID: 33672887 DOI
  • Serum Acylcarnitines Associated with High Short-Term Mortality in Patients with Alcoholic Hepatitis. AlcoholGut–Brain Gao B, Argemi J, Bataller R, Schnabl B. Biomolecules. 2021 Feb. PMID: 33672832 DOI
  • Differential blood DNA methylation across Lewy body dementias. Genetics Nasamran CA, Sachan ANS, Mott J, Kuras YI, Scherzer CR, Study HB, Ricciardelli E, Jepsen K, Edland SD, Fisch KM, Desplats P. Alzheimers Dement (Amst). 2021 Feb. PMID: 33665346 DOI
  • Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. PARC AlcoholGeneticsBehavior McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. Neuropharmacology. 2021 Feb. PMID: 33647278 DOI
  • Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Gut–Brain Zhou R, Llorente C, Cao J, Zaramela LS, Zeng S, Gao B, Li SZ, Welch RD, Huang FQ, Qi LW, Pan C, Huang Y, Zhou P, Beussen I, Zhang Y, Bryam G, Fiehn O, Wang L, Liu EH, Yu RT, Downes M, Evans RM, Goglin K, Fouts DE, Brenner DA, Bode L, Fan X, Zengler K, Schnabl B. Cell Mol Gastroenterol Hepatol. 2021 Feb. PMID: 33631374 DOI
  • Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation. Genetics Zhou Y, Bastian IN, Long MD, Dow M, Li W, Liu T, Ngu RK, Antonucci L, Huang JY, Phung QT, Zhao XH, Banerjee S, Lin XJ, Wang H, Dang B, Choi S, Karin D, Su H, Ellisman MH, Jamieson C, Bosenberg M, Cheng Z, Haybaeck J, Kenner L, Fisch KM, Bourgon R, Hernandez G, Lill JR, Liu S, Carter H, Mellman I, Karin M, Shalapour S. Proc Natl Acad Sci U S A. 2021 Feb. PMID: 33602823 DOI
  • Reelin deficiency contributes to long-term behavioral abnormalities induced by chronic adolescent exposure to Δ9-tetrahydrocannabinol in mice. Behavior Iemolo A, Montilla-Perez P, Nguyen J, Risbrough VB, Taffe MA, Telese F. Neuropharmacology. 2021 Feb. PMID: 33582152 DOI
  • New Developments in Microbiome in Alcohol-Associated and Nonalcoholic Fatty Liver Disease. AlcoholGut–Brain Hartmann P, Schnabl B. Semin Liver Dis. 2021 Jan. PMID: 33957682 DOI
  • Trajectory of Serum Bilirubin Predicts Spontaneous Recovery in a Real-World Cohort of Patients With Alcoholic Hepatitis. Alcohol Parker R, Cabezas J, Altamirano J, Arab JP, Ventura-Cots M, Sinha A, Dhanda A, Arrese M, McCune CA, Rowe IA, Schnabl B, Mathurin P, Shawcross D, Abraldes JG, Lucey MR, Garcia-Tsao G, Verna E, Brown RS, Bosques-Padilla F, Vargas V, Louvet A, Holt AP, Bataller R. Clin Gastroenterol Hepatol. 2021 Jan. PMID: 33516950 DOI
  • Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution. Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. Cell Rep. 2021 Jan. PMID: 33503434 DOI
  • Sensitivity to food and cocaine cues are independent traits in a large sample of heterogeneous stock rats. PARC StimulantsBehavior King CP, Tripi JA, Hughson AR, Horvath AP, Lamparelli AC, Holl KL, Chitre AS, Polesskaya O, Ishiwari K, Solberg Woods LC, Palmer AA, Robinson TE, Flagel SB, Meyer PJ. Sci Rep. 2021 Jan. PMID: 33500444 DOI
  • Genetic and Pharmacological Manipulations of Glyoxalase 1 Mediate Ethanol Withdrawal Seizure Susceptibility in Mice. AlcoholGeneticsBehavior Barkley-Levenson AM, Lee A, Palmer AA. Brain Sci. 2021 Jan. PMID: 33478138 DOI
  • A Perspective Of Intestinal Immune-Microbiome Interactions In Alcohol-Associated Liver Disease. AlcoholGut–Brain Bruellman R, Llorente C. Int J Biol Sci. 2021 Jan. PMID: 33390852 DOI

2020

  • The Cannabinoid Receptor Agonist, WIN-55212-2, Suppresses the Activation of Proinflammatory Genes Induced by Interleukin 1 Beta in Human Astrocytes. Fields JA, Swinton MK, Montilla-Perez P, Ricciardelli E, Telese F. Cannabis Cannabinoid Res. 2020 Dec. PMID: 33998879 DOI
  • Gut dysbiosis as a driver in alcohol-induced liver injury. AlcoholGut–Brain Fairfield B, Schnabl B. JHEP Rep. 2020 Dec. PMID: 33598648 DOI
  • Persistent SARS-CoV-2 RNA Positive in Feces but Negative in Breastmilk: A Case Report of COVID-19 in a Breastfeeding Patient. Gut–Brain Chu H, Li J, Yan J, Bai T, Schnabl B, Zou L, Yang L, Hou X. Front Med (Lausanne). 2020 Dec. PMID: 33344466 DOI
  • Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma. Gut–Brain Zhang Q, Ma C, Duan Y, Heinrich B, Rosato U, Diggs LP, Ma L, Roy S, Fu Q, Brown ZJ, Wabitsch S, Thovarai V, Fu J, Feng D, Ruf B, Cui LL, Subramanyam V, Frank KM, Wang S, Kleiner DE, Ritz T, Rupp C, Gao B, Longerich T, Kroemer A, Wang XW, Ruchirawat M, Korangy F, Schnabl B, Trinchieri G, Greten TF. Cancer Discov. 2020 Dec. PMID: 33323397 DOI
  • Gut microbiome, liver immunology, and liver diseases. AlcoholGut–Brain Wang R, Tang R, Li B, Ma X, Schnabl B, Tilg H. Cell Mol Immunol. 2020 Dec. PMID: 33318628 DOI
  • Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes. Alcohol Wang Z, Wang Y, Bradbury N, Gonzales Bravo C, Schnabl B, Di Nardo A. Sci Rep. 2020 Dec. PMID: 33303806 DOI
  • Current Concepts, Opportunities, and Challenges of Gut Microbiome-Based Personalized Medicine in Nonalcoholic Fatty Liver Disease. AlcoholGut–Brain Sharpton SR, Schnabl B, Knight R, Loomba R. Cell Metab. 2020 Dec. PMID: 33296678 DOI
  • Abstinence from ethanol dependence produces concomitant cortical gray matter abnormalities, microstructural deficits and cognitive dysfunction. AlcoholBrain ImagingBehavior Somkuwar SS, Villalpando EG, Quach LW, Head BP, McKenna BS, Scadeng M, Mandyam CD. Eur Neuropsychopharmacol. 2020 Dec. PMID: 33279357 DOI
  • Correction: ACNP efforts toward reducing climate change. Jordan CJ, Palmer AA. Neuropsychopharmacology. 2020 Dec. PMID: 32884099 DOI
  • A New Era for Space Life Science: International Standards for Space Omics Processing. Rutter L, Barker R, Bezdan D, Cope H, Costes SV, Degoricija L, Fisch KM, Gabitto MI, Gebre S, Giacomello S, Gilroy S, Green SJ, Mason CE, Reinsch SS, Szewczyk NJ, Taylor DM, Galazka JM, Herranz R, Muratani M. Patterns (N Y). 2020 Nov. PMID: 33336201 DOI
  • Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Genetics da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. Cell. 2020 Nov. PMID: 33242417 DOI
  • Microbiome of the Aerodigestive Tract in Health and Esophageal Disease. Gut–Brain Hasan A, Hasan LK, Schnabl B, Greytak M, Yadlapati R. Dig Dis Sci. 2020 Nov. PMID: 33236315 DOI
  • Targeting pathobionts for the treatment of alcohol-associated liver disease. AlcoholGut–Brain Lang S, Demir M, Schnabl B. Liver Int. 2020 Nov. PMID: 33159427 DOI
  • The gut mycobiome: a novel player in chronic liver diseases. Gut–Brain Jiang L, Stärkel P, Fan JG, Fouts DE, Bacher P, Schnabl B. J Gastroenterol. 2020 Nov. PMID: 33151407 DOI
  • Multicenter Analysis of Liver Injury Patterns and Mortality in COVID-19. Gut–Brain Chu H, Bai T, Chen L, Hu L, Xiao L, Yao L, Zhu R, Niu X, Li Z, Zhang L, Han C, Song S, He Q, Zhao Y, Zhu Q, Chen H, Schnabl B, Yang L, Hou X. Front Med (Lausanne). 2020 Oct. PMID: 33195339 DOI
  • Metabolomic profiles associated with a mouse model of antipsychotic-induced food intake and weight gain. Zapata RC, Rosenthal SB, Fisch K, Dao K, Jain M, Osborn O. Sci Rep. 2020 Oct. PMID: 33122657 DOI
  • Modeling epistasis in mice and yeast using the proportion of two or more distinct genetic backgrounds: Evidence for "polygenic epistasis". Genetics Rau CD, Gonzales NM, Bloom JS, Park D, Ayroles J, Palmer AA, Lusis AJ, Zaitlen N. PLoS Genet. 2020 Oct. PMID: 33104702 DOI
  • Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research. Genetics Sigmon JS, Blanchard MW, Baric RS, Bell TA, Brennan J, Brockmann GA, Burks AW, Calabrese JM, Caron KM, Cheney RE, Ciavatta D, Conlon F, Darr DB, Faber J, Franklin C, Gershon TR, Gralinski L, Gu B, Gaines CH, Hagan RS, Heimsath EG, Heise MT, Hock P, Ideraabdullah F, Jennette JC, Kafri T, Kashfeen A, Kulis M, Kumar V, Linnertz C, Livraghi-Butrico A, Lloyd KCK, Lutz C, Lynch RM, Magnuson T, Matsushima GK, McMullan R, Miller DR, Mohlke KL, Moy SS, Murphy CEY, Najarian M, O'Brien L, Palmer AA, Philpot BD, Randell SH, Reinholdt L, Ren Y, Rockwood S, Rogala AR, Saraswatula A, Sassetti CM, Schisler JC, Schoenrock SA, Shaw GD, Shorter JR, Smith CM, St Pierre CL, Tarantino LM, Threadgill DW, Valdar W, Vilen BJ, Wardwell K, Whitmire JK, Williams L, Zylka MJ, Ferris MT, McMillan L, Manuel de Villena FP. Genetics. 2020 Oct. PMID: 33067325 DOI
  • Targeting the gut-liver-immune axis to treat cirrhosis. Gut–Brain Tranah TH, Edwards LA, Schnabl B, Shawcross DL. Gut. 2020 Oct. PMID: 33060124 DOI
  • OpenVape: An Open-Source E-Cigarette Vapor Exposure Device for Rodents. NicotineGut–BrainBehavior Frie JA, Underhill J, Zhao B, de Guglielmo G, Tyndale RF, Khokhar JY. eNeuro. 2020 Oct. PMID: 32859723 DOI
  • Intestinal Virome in Patients With Alcoholic Hepatitis. AlcoholGeneticsGut–Brain Jiang L, Lang S, Duan Y, Zhang X, Gao B, Chopyk J, Schwanemann LK, Ventura-Cots M, Bataller R, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Ho SB, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Kisseleva T, Brenner DA, Tu XM, Stärkel P, Pride D, Fouts DE, Schnabl B. Hepatology. 2020 Oct. PMID: 32654263 DOI
  • Gut Microbiota-Derived Propionate Regulates the Expression of Reg3 Mucosal Lectins and Ameliorates Experimental Colitis in Mice. Gut–Brain Bajic D, Niemann A, Hillmer AK, Mejias-Luque R, Bluemel S, Docampo M, Funk MC, Tonin E, Boutros M, Schnabl B, Busch DH, Miki T, Schmid RM, van den Brink MRM, Gerhard M, Stein-Thoeringer CK. J Crohns Colitis. 2020 Oct. PMID: 32227170 DOI
  • Tumor necrosis factor alpha receptor 1 deficiency in hepatocytes does not protect from non-alcoholic steatohepatitis, but attenuates insulin resistance in mice. AlcoholGut–Brain Bluemel S, Wang Y, Lee S, Schnabl B. World J Gastroenterol. 2020 Sep. PMID: 32952340 DOI
  • Virtual meetings: A critical step to address climate change. Jordan CJ, Palmer AA. Sci Adv. 2020 Sep. PMID: 32938670 DOI
  • From intestinal dysbiosis to alcohol-associated liver disease. AlcoholGut–Brain Mendes BG, Schnabl B. Clin Mol Hepatol. 2020 Sep. PMID: 32911590 DOI
  • Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose. PARC Genetics Chitre AS, Polesskaya O, Holl K, Gao J, Cheng R, Bimschleger H, Garcia Martinez A, George T, Gileta AF, Han W, Horvath A, Hughson A, Ishiwari K, King CP, Lamparelli A, Versaggi CL, Martin C, St Pierre CL, Tripi JA, Wang T, Chen H, Flagel SB, Meyer P, Richards J, Robinson TE, Palmer AA, Solberg Woods LC. Obesity (Silver Spring). 2020 Aug. PMID: 32860487 DOI
  • HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers. Genetics Ren S, Gaykalova DA, Guo T, Favorov AV, Fertig EJ, Tamayo P, Callejas-Valera JL, Allevato M, Gilardi M, Santos J, Fukusumi T, Sakai A, Ando M, Sadat S, Liu C, Xu G, Fisch KM, Wang Z, Molinolo AA, Gutkind JS, Ideker T, Koch WM, Califano JA. Oncogene. 2020 Aug. PMID: 32848210 DOI
  • ACNP efforts toward reducing climate change. Jordan CJ, Palmer AA. Neuropsychopharmacology. 2020 Aug. PMID: 32791512 DOI
  • Microbiota and Fatty Liver Disease-the Known, the Unknown, and the Future. AlcoholGut–Brain Lang S, Schnabl B. Cell Host Microbe. 2020 Aug. PMID: 32791115 DOI
  • Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. PARC NicotineBehavior Smith LC, George O. Neuropharmacology. 2020 Aug. PMID: 32758566 DOI
  • Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice. AlcoholGut–Brain Zhou R, Llorente C, Cao J, Gao B, Duan Y, Jiang L, Wang Y, Kumar V, Stärkel P, Bode L, Fan X, Schnabl B. Alcohol Clin Exp Res. 2020 Aug. PMID: 32628772 DOI
  • DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain. Brain ImagingBehavior Deslauriers J, Toth M, Scadeng M, McKenna BS, Bussell R, Gresack J, Rissman R, Risbrough VB, Brown GG. Psychiatry Res Neuroimaging. 2020 Jul. PMID: 32731113 DOI
  • The Latent Genetic Structure of Impulsivity and Its Relation to Internalizing Psychopathology. Genetics Gustavson DE, Friedman NP, Fontanillas P, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S. Psychol Sci. 2020 Jul. PMID: 32716714 DOI
  • Changes in the fecal bacterial microbiota associated with disease severity in alcoholic hepatitis patients. AlcoholGut–Brain Lang S, Fairfied B, Gao B, Duan Y, Zhang X, Fouts DE, Schnabl B. Gut Microbes. 2020 Jul. PMID: 32684075 DOI
  • Transcriptomic Profiling Identifies Novel Hepatic and Intestinal Genes Following Chronic Plus Binge Ethanol Feeding in Mice. AlcoholGut–Brain Jiang L, Chu H, Gao B, Lang S, Wang Y, Duan Y, Schnabl B. Dig Dis Sci. 2020 Jul. PMID: 32671585 DOI
  • Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease. AlcoholGeneticsGut–Brain Lang S, Demir M, Martin A, Jiang L, Zhang X, Duan Y, Gao B, Wisplinghoff H, Kasper P, Roderburg C, Tacke F, Steffen HM, Goeser T, Abraldes JG, Tu XM, Loomba R, Stärkel P, Pride D, Fouts DE, Schnabl B. Gastroenterology. 2020 Jul. PMID: 32652145 DOI
  • Microbial Products and Metabolites Contributing to Alcohol-Related Liver Disease. AlcoholGut–Brain Gao B, Emami A, Nath S, Schnabl B. Mol Nutr Food Res. 2020 Jul. PMID: 32583604 DOI
  • Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know? AlcoholGut–Brain Jiang L, Schnabl B. Physiology (Bethesda). 2020 Jul. PMID: 32490750 DOI
  • Adapting Genotyping-by-Sequencing and Variant Calling for Heterogeneous Stock Rats. PARC Genetics Gileta AF, Gao J, Chitre AS, Bimschleger HV, St Pierre CL, Gopalakrishnan S, Palmer AA. G3 (Bethesda). 2020 Jul. PMID: 32398234 DOI
  • Functional Microbiomics Reveals Alterations of the Gut Microbiome and Host Co-Metabolism in Patients With Alcoholic Hepatitis. AlcoholGeneticsGut–Brain Gao B, Duan Y, Lang S, Barupal D, Wu TC, Valdiviez L, Roberts B, Choy YY, Shen T, Byram G, Zhang Y, Fan S, Wancewicz B, Shao Y, Vervier K, Wang Y, Zhou R, Jiang L, Nath S, Loomba R, Abraldes JG, Bataller R, Tu XM, Stärkel P, Lawley TD, Fiehn O, Schnabl B. Hepatol Commun. 2020 Jun. PMID: 32766476 DOI
  • VTA Glutamate Neuron Activity Drives Positive Reinforcement Absent Dopamine Co-release. GeneticsBehavior Zell V, Steinkellner T, Hollon NG, Warlow SM, Souter E, Faget L, Hunker AC, Jin X, Zweifel LS, Hnasko TS. Neuron. 2020 Jun. PMID: 32610039 DOI
  • Intestinal permeability, microbial translocation, changes in duodenal and fecal microbiota, and their associations with alcoholic liver disease progression in humans. AlcoholGut–Brain Maccioni L, Gao B, Leclercq S, Pirlot B, Horsmans Y, De Timary P, Leclercq I, Fouts D, Schnabl B, Stärkel P. Gut Microbes. 2020 Jun. PMID: 32588725 DOI
  • The selective PPAR-delta agonist seladelpar reduces ethanol-induced liver disease by restoring gut barrier function and bile acid homeostasis in mice. AlcoholGut–Brain Chu H, Jiang L, Gao B, Gautam N, Alamoudi JA, Lang S, Wang Y, Duan Y, Alnouti Y, Cable EE, Schnabl B. Transl Res. 2020 Jun. PMID: 32553670 DOI
  • Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. PARC NicotineBehavior Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. Neuropsychopharmacology. 2020 Jun. PMID: 32544927 DOI
  • Single cell transcriptomics reveals opioid usage evokes widespread suppression of antiviral gene program. OpioidsBehavior Karagiannis TT, Cleary JP, Gok B, Henderson AJ, Martin NG, Yajima M, Nelson EC, Cheng CS. Nat Commun. 2020 May. PMID: 32457298 DOI
  • Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits. PARC AlcoholGeneticsBehavior Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J. Nat Neurosci. 2020 May. PMID: 32451486 DOI
  • Aberrant expression of CPSF1 promotes head and neck squamous cell carcinoma via regulating alternative splicing. Genetics Sakai A, Ando M, Fukusumi T, Ren S, Liu C, Qualliotine J, Haft S, Sadat S, Saito Y, Guo TW, Xu G, Sasik R, Fisch KM, Gutkind JS, Fertig EJ, Molinolo AA, Califano JA. PLoS One. 2020 May. PMID: 32437477 DOI
  • Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats. PARC GeneticsGut–BrainBehavior Peterson VL, Richards JB, Meyer PJ, Cabrera-Rubio R, Tripi JA, King CP, Polesskaya O, Baud A, Chitre AS, Bastiaanssen TFS, Woods LS, Crispie F, Dinan TG, Cotter PD, Palmer AA, Cryan JF. EBioMedicine. 2020 May. PMID: 32403084 DOI
  • Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. PARC OpioidsGeneticsGut–BrainBehavior Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. eNeuro. 2020 May. PMID: 32341122 DOI
  • Functional Microbial Responses to Alcohol Abstinence in Patients With Alcohol Use Disorder. AlcoholGeneticsGut–Brain Gao B, Emami A, Zhou R, Lang S, Duan Y, Wang Y, Jiang L, Loomba R, Brenner DA, Stärkel P, Schnabl B. Front Physiol. 2020 Apr. PMID: 32390870 DOI
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  • Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. PARC OpioidsBehavior de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. Front Behav Neurosci. 2020 Jan. PMID: 31992976 DOI
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  • Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. PARC OpioidsGeneticsBehavior Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. Proc Natl Acad Sci U S A. 2020 Jan. PMID: 31932450 DOI
  • Genome-wide Associations Reveal Human-Mouse Genetic Convergence and Modifiers of Myogenesis, CPNE1 and STC2. Genetics Hernandez Cordero AI, Gonzales NM, Parker CC, Sokoloff G, Vandenbergh DJ, Cheng R, Abney M, Skol A, Douglas A, Palmer AA, Gregory JS, Lionikas A. Am J Hum Genet. 2020 Jan. PMID: 31901248 DOI
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